SEROPREVALENCE AND PROSPECTIVE RISK FACTOR ANALYSIS OF CYTOMEGALOVIRUS (CMV)

巨细胞病毒（CMV）的血清阳性率和前瞻性危险因素分析

• 批准号: 7605423
• 负责人: Susan L Rosenthal
• 金额: $ 3.33万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605423
• 关键词: Adolescence; Adult; Age-Years; Blood; Cessation of life; Child; Computer Retrieval of Information on Scientific Projects Database; Computers; Cytomegalovirus; Cytomegalovirus Infections; Cytomegalovirus Vaccines; Data; Disease; Educational process of instructing; Experimental Designs; Factor Analysis; Female; Female of child bearing age; Funding; Future; Goals; Grant; Household; Immune system; Individual; Infant; Infection; Institution; Knowledge; Lead; Life; Male Adolescents; Persons; Phase; Population; Procedures; Questionnaires; Research; Research Personnel; Resources; Risk; Risk Factors; Saliva; Sampling; Seroprevalences; Source; Study Subject; Testing; United States; United States National Institutes of Health; Urine; Virus; boys; disability; early childhood; prevent; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Cytomegalovirus (CMV) is an important cause of illness, and even sometimes death, in infants, as well as children and adults whose immune systems are weak. Each year in the United States (US), an estimated 8000 infants suffer disabilities if they are born with CMV infection. Traditionally, studies about CMV have focused on women of child-bearing age as the primary population to receive a CMV vaccine to prevent CMV from hurting their babies. While most people are infected with CMV at some point in their lives, this infection typically occurs during either early childhood or during adolescence. Though there have been studies about CMV in both young and older females, in general, less is known about how adolescent males get CMV. Hypothesis: The goals of this study are to identify different risks factors associated with getting CMV and how common the virus is in adolescent males. Specific Aims and Procedures (summary): The aims of the study are broken up into three different phases. Phase I is to determine how common CMV is in adolescent males and to identify risk factors of these boys for getting CMV. Phase II is to study how many adolescent males get CMV over two years and to identify the risk factors associated with getting it. Finally, Phase III is to determine how much virus is in the blood, urine, and saliva of those adolescent boys who were infected with CMV during Phase II. Experimental Design (summary): In Phases I and II of the study, subjects will complete a questionnaire by computer, investigating possible risk factors for CMV, including household and environmental practices. For those subjects who are 14 years of age or older, this will include questions about sexual practices. In Phases I, II, and III, blood will be drawn to test for CMV; in Phases II and III, urine will be collected to test for CMV; finally, in Phase III, saliva will also be collected to test the amount CMV present in the samples. Significance (summary): Knowledge gained by collecting data about how common CMV is in adolescent boys will lead to future studies about CMV vaccines. Studying the risk factors associated with getting CMV and the amount of CMV in blood, urine, and saliva, may help teach individuals about how CMV is passed from person to person and who is at greatest risk for getting the disease.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 背景资料： 巨细胞病毒（CMV）是婴儿以及免疫系统较弱的儿童和成人患病甚至死亡的重要原因。 在美国，每年估计有8000名婴儿因出生时感染CMV而致残。 传统上，关于CMV的研究集中在育龄妇女作为接受CMV疫苗以防止CMV伤害婴儿的主要人群。 虽然大多数人在生活中的某个时候感染了CMV，但这种感染通常发生在儿童早期或青春期。 虽然有关于年轻和老年女性CMV的研究，但一般来说，对青少年男性如何感染CMV知之甚少。 假设： 这项研究的目的是确定与获得CMV相关的不同风险因素以及该病毒在青少年男性中的常见程度。 具体目标和程序（摘要）： 研究的目的分为三个不同的阶段。 第一阶段是确定CMV在青少年男性中的常见程度，并确定这些男孩感染CMV的风险因素。 第二阶段是研究在两年内有多少青少年男性感染了CMV，并确定与感染CMV相关的风险因素。最后，第三阶段是确定在第二阶段感染CMV的青少年男孩的血液、尿液和唾液中有多少病毒。 实验设计（总结）： 在研究的第一阶段和第二阶段，受试者将通过计算机完成一份问卷，调查CMV的可能风险因素，包括家庭和环境实践。对于14岁或以上的受试者，这将包括有关性行为的问题。 在第I、II和III阶段，将抽取血液检测CMV;在第II和III阶段，将采集尿液检测CMV;最后，在第III阶段，还将采集唾液检测样本中存在的CMV量。 意义（总结）： 通过收集关于CMV在青春期男孩中有多常见的数据获得的知识将导致未来关于CMV疫苗的研究。 研究与获得CMV相关的风险因素以及血液，尿液和唾液中CMV的数量，可能有助于教导人们CMV如何从一个人传递到另一个人，以及谁是获得这种疾病的最大风险。