SEROPREVALENCE AND PROSPECTIVE RISK FACTOR ANALYSIS OF CYTOMEGALOVIRUS (CMV)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 巨细胞病毒（CMV）是婴儿以及免疫系统较弱的儿童和成人患病甚至死亡的重要原因。虽然有关于年轻和老年女性CMV的研究，但一般来说，对青少年男性如何感染CMV知之甚少。 这项研究的目的是确定与获得CMV相关的不同风险因素以及该病毒在青少年男性中的常见程度。 研究的目的分为三个不同的阶段。 第一阶段是确定CMV在青少年男性中的常见程度，并确定危险因素。第二阶段是研究有多少青少年男性在两年内感染CMV，并确定危险因素。 最后，第三阶段是确定在第二阶段期间感染CMV的青少年男孩的血液、尿液和唾液中有多少病毒。 在研究的I期和II期，受试者将通过计算机完成一份问卷，调查CMV的可能风险因素，包括性行为、家庭和环境实践。在第I、II和III阶段，将抽取血液检测CMV;在第II和III阶段，将采集尿液检测CMV;最后，在第III阶段，还将采集唾液检测样本中存在的CMV量。通过收集关于CMV在青春期男孩中有多常见的数据获得的知识将导致未来关于CMV疫苗的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cytomegalovirus (CMV) is an important cause of illness, and even sometimes death, in infants, as well as children and adults whose immune systems are weak. Though there have been studies about CMV in both young and older females, in general, less is known about how adolescent males get CMV. The goals of this study are to identify different risks factors associated with getting CMV and how common the virus is in adolescent males. The aims of the study are broken up into three different phases. Phase I is to determine how common CMV is in adolescent males and to identify risk factors. Phase II is to study how many adolescent males get CMV over two years and to identify the risk factors. Finally, Phase III is to determine how much virus is in the blood, urine, and saliva of those adolescent boys who were infected with CMV during Phase II. In Phases I and II of the study, subjects will complete a questionnaire by computer, investigating possible risk factors for CMV, including, sexual practices, and household and environmental practices. In Phases I, II, and III, blood will be drawn to test for CMV; in Phases II and III, urine will be collected to test for CMV; finally, in Phase III, saliva will also be collected to test the amount CMV present in the samples. Knowledge gained by collecting data about how common CMV is in adolescent boys will lead to future studies about CMV vaccines.