Adolescent and Parental Attitudes About STI Prevention Trial Participation

描述（由申请人提供）：贝尔蒙特报告的“正义”概念意味着青少年应该参与有关性传播感染的研究，因为他们的感染率很高。然而，他们也是一个“弱势”群体，这意味着他们应该受益于父母的指导，而不是在他们的决策中受到不适当的影响。了解父母和青少年在参与意愿（WTP）上的不一致，有助于制定策略，以确保双方都能接受最终的决定。决策受到发展特点的影响，因此，鉴于青春期的迅速变化，随着时间的推移会发生变化。局部杀微生物剂的安全性试验将是检查WTP的背景，允许适用于其他试验类型。具体目标：（1）描述发展特征之间的关系（认知和相关经验、父母教养和家庭变量）和支付意愿、对隐私和父母影响的态度以及在性传播感染预防研究背景下的不一致性; 2）描述发育特征变化之间的关系（认知和相关经验，养育和家庭关系）随着时间和支付意愿以及对隐私和父母影响的态度，3）描述不一致的父母管理，因为它涉及到的显着方面的试验和不一致的父母干预风格的看法，因为它涉及到的不一致和满意度的最后决定参与的背景下，在WTP的STI预防研究。方法：将采用多层次策略从初级保健诊所招募14-17岁的男性和女性青少年及其父母。将在决策的所有阶段获得关于不参与的数据，以便收集通常不参与研究的父母和青少年的信息。使用假设的临床试验可以对不参加试验的家庭进行评估。父母和青少年将同时接受两个不同的采访，然后完成一个联合采访，这将是录像的互动编码。为了评估发展变化的影响，参与者将在一年后再次接受采访。成果：这些信息将用于制定和评估干预措施，这些干预措施旨在为青少年提供参与研究的机会，尽可能多地得到父母的指导，并使他们能够自主做出决定。

DESCRIPTION (provided by applicant): The Belmont Report's concept of "justice" means adolescents should participate in studies regarding sexually transmitted infections, given their high rates of infection. Yet they are also a "vulnerable" population, which means they should benefit from parental guidance without being inappropriately influenced in their decision-making. Understanding parent-adolescent discordance about willingness to participate (WTP) helps develop strategies to insure that both are comfortable with the final decision. Decision-making is influenced by developmental characteristics, thus, given the rapid changes during adolescence there will be changes over time. A safety trial of topical microbicides will be the context in which to examine WTP, allowing for applicability to other trial types. Specific Aims: 1) Describe the relationship between developmental characteristics (cognition and relevant experience, parenting and family variables) and WTP, attitudes towards privacy and parental influence, and discordance in the context of a study of STI prevention; 2) Describe the relationship between changes in developmental characteristics (cognition and relevant experience, parenting and family relationships) over time and WTP and attitudes towards privacy and parental influence, and discordance in WTP in the context of a study of STI prevention; 3) Describe adolescent-parent management of discordance as it relates to perceptions of the salient aspects of the trial and adolescent-parent interactional style as it relates to discordance and satisfaction with the final decision regarding participation. Methods: A multi-level strategy will be used to recruit 14-17 year old male and female adolescents and parents from primary care clinics. Data about non-participation will be obtained at all stages of decision-making in order to collect information about parents and adolescents who would normally not participate in research. The use of a hypothetical clinical trial allows for assessment of families who would not participate in trials. Parents and adolescents will be interviewed simultaneously by two different interviewers, and then complete a joint interview, which will be videotaped for coding of the interaction. To evaluate the impact of developmental change, participants will be re-interviewed one year later. Outcomes: This information will be used to develop and evaluate interventions designed to provide adolescents the opportunity to participate in studies with as much guidance as needed from parents and the autonomy to make their own decision.