MECHANISMS OF FOOD HYPERSENSITIVITY IN ATOPIC DERMATITIS

特应性皮炎食物过敏的机制

• 批准号: 7605265
• 负责人: Hugh A Sampson
• 金额: $ 5.96万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605265
• 关键词: Atopic Dermatitis; Blinded; Child; Computer Retrieval of Information on Scientific Projects Database; Disease; Food; Food Hypersensitivity; Funding; Grant; IgE; Immunologics; Institution; Mediating; Natural History; Newborn Infant; Prophylactic treatment; Purpose; Research; Research Personnel; Resources; Risk; Role; Skin; Source; Symptoms; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies of dietary prophylaxis in newborns at high risk for atopic disease, and provocation of skin symptoms and immunologic changes by blinded food challenges strongly suggest a significant pathogenic role for IgE-mediated FH in AD. The purpose of this research is to more precisely define the natural history and immunopathogenic mechanisms of food hypersensitivity (FH) in children with atopic dermatitis (AD).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 对特应性疾病高危新生儿的饮食预防研究，以及盲目食物挑战引起的皮肤症状和免疫学变化的研究强烈表明，IgE 介导的 FH 在 AD 中具有重要的致病作用。 本研究的目的是更准确地定义特应性皮炎（AD）儿童食物过敏（FH）的自然史和免疫致病机制。