Microtubule stabilisation: promoting adaptive plasticity, brain healing and functional recovery after traumatic brain injury

微管稳定：促进脑外伤后的适应性可塑性、脑愈合和功能恢复

• 批准号: nhmrc : 1042556
• 负责人: Prof Tracey Dickson
• 金额: $ 33.82万
• 依托单位: Antarctic Climate and Ecosystems CRC, University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microtubule-stabilisation-promoting-brain-injury/111487
• 关键词: Microtubule; stabilisation; promoting; adaptive; plasticity

Traumatic brain injury (TBI) continues to be the leading cause of death and disability for individuals under 45 years of age. There are currently no effective pharmacotherapeutics available that are able to prevent or minimise brain damage following TBI. My team will use sophisticated in vivo techniques to fully characterise the brain's response to injury and to test whether microtubule stabilisation via new generation taxol-like drugs improves post-trauma outcomes.

创伤性脑损伤（TBI）仍然是45岁以下人群死亡和残疾的主要原因。目前还没有有效的药物治疗能够预防或最大限度地减少TBI后的脑损伤。我的团队将使用复杂的体内技术来完全验证大脑对损伤的反应，并测试通过新一代紫杉醇类药物稳定微管是否改善创伤后结果。