Microfluidic technology to help understand physical damage to brain cells

微流体技术有助于了解脑细胞的物理损伤

• 批准号: DP150100998
• 负责人: Prof Tracey Dickson
• 金额: $ 28.56万
• 依托单位: University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150100998
• 关键词: Microfluidic; technology; help; understand; physical

Understanding the organisation, structure and mechanisms of the human brain and nervous system remains one of the biggest challenges of science. This project aims to develop a new cell culture platform to form defined molecular networks of brain cells and to monitor changes throughout the network in response to a small localised injury within the network. This innovative platform will be used to help understand changes within cells in response to physical damage to networks of brain cells. This is one of the major causes of death and disability in developed nations, and is identified as a risk factor for a range of neurodegenerative diseases including Alzheimer's, Parkinson's and motor neuron disease.

了解人类大脑和神经系统的组织、结构和机制仍然是科学的最大挑战之一。该项目旨在开发一种新的细胞培养平台，以形成明确的脑细胞分子网络，并监测整个网络对网络内小的局部损伤的反应变化。这个创新的平台将被用来帮助理解脑细胞网络受到物理损伤后细胞内部的变化。这是发达国家死亡和残疾的主要原因之一，并被确定为一系列神经退行性疾病的风险因素，包括阿尔茨海默氏症、帕金森氏症和运动神经元疾病。