Microfluidic models of the CNS: Understanding cells, circuits & synapses

中枢神经系统的微流体模型：了解细胞、电路

• 批准号: DP200103193
• 负责人: Prof Tracey Dickson
• 金额: $ 38.36万
• 依托单位: University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-11-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200103193
• 关键词: Microfluidic; models; CNS; Understanding; cells

Aims: We aim to develop new cell culture platforms to form defined networks of brain cells. These platforms will be used to determine the critical mechanisms underpinning central nervous system function. Significance: The devices developed will enable an unprecedented capacity to monitor changes throughout a network, with analysis at the level of the synapse, cell and circuit. Expected outcomes: We will advance knowledge regarding the function of the CNS and deliver complex human cellular systems, that have both discovery and commercial applications. Benefit: These platforms will have subsequent application revealing the mechanisms underlying numerous neurological diseases, with capacity to upscale for rapid drug screening.

目的：我们的目标是开发新的细胞培养平台，形成明确的脑细胞网络。这些平台将用于确定支撑中枢神经系统功能的关键机制。