Post-transcriptional Control of Gene Expression: Mechanisms of mRNA Decay

基因表达的转录后控制：mRNA 衰变机制

• 批准号: 7638497
• 负责人: WILLIAM F. MARZLUFF
• 金额: --
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7638497
• 关键词: Address; American; Area; Attention; Biological; Biological Sciences; Biology; Cell Nucleus; Clinical; Colorado; Communities; Development; Disclosure; Disease; Ensure; Eukaryota; Event; Fellowship; Fertilization; Funding; Gene Expression; Genetic Transcription; Germany; Growth; Growth and Development function; Massachusetts; Messenger RNA; Molecular; Organism; Pathway interactions; Pharmacologic Substance; Plague; Post-Transcriptional Regulation; Process; Prokaryotic Cells; Quality Control; RNA; RNA Decay; RNA Interference; RNA Processing; RNA-Binding Proteins; Regulation; Regulator Genes; Request for Proposals; Research; Research Personnel; Resort; Role; Scientist; Series; Small RNA; Societies; Staging; Structure; Structure-Activity Relationship; Transcript; Translating; Translation Process; Translations; Travel; Work; abstracting; base; biological systems; falls; graduate student; insight; interest; mRNA Decay; mRNA Stability; mRNA Surveillance; meetings; novel; posters; programs; symposium

DESCRIPTION (provided by applicant): We are requesting partial support for a FASEB Conference on "Post-Transcriptional Regulation of Gene Expression: Mechanisms of mRNA Decay", to be held in Snowmass Village, CO on June 24-29, 2006. Turnover of mRNA is a key, but frequently unrecognized, regulator of gene expression. The stability of an mRNA dictates its ultimate steady-state level. Programmed instability is an important mechanism of repressing gene expression, and the surveillance of mRNA quality ensures that only "fit" transcripts exit the nucleus and are translated, while RNA interference relies on selective mRNA turnover for its biological consequences, whereas novel pharmaceuticals are targeting mRNA decay pathways. For these reasons, mRNA turnover is attracting heightened interest from all areas of the life sciences. The proposed FASEB Conference is unique in concentrating on mRNA decay, thereby exploring in diverse biological settings the mechanisms, both at the cellular and molecular levels that underpin this universal process. The proposed meeting is particularly noteworthy in attracting investigators who study both prokaryotic and eukaryotic organisms, and in focusing on mechanisms by which RNAs interact with the decay apparatus, the translation apparatus, and the factors which modulate decay. The meeting's sessions will address decay events specific for mRNA 5' or 3' termini and their subcellular localization; structure/function relationships in RNA binding proteins, small RNAs, and other decay factors; the interplay of mRNA decay with the processes of translation and transcription; RNA quality control and related regulatory networks; and the clinical and pharmaceutical relevance of mRNA decay. It is anticipated that the presentations at the meeting will include the first public disclosures of several key structures and mechanisms, as well as provide novel insights for the regulation of growth, development, and disease. In short, the conference will provide an overview of the latest progress in an exciting field and will propel the next stage of its development.

描述（由申请人提供）：我们要求在2006年6月24日至29日在科罗拉多州雪虫村庄举行的关于“基因表达后的转录后调节：mRNA衰变机制”的FaseB会议。MRNA的失误是关键，但经常未认识到基因表达的调节剂。 mRNA的稳定性决定了其最终的稳态水平。 编程的不稳定性是抑制基因表达的重要机制，而mRNA质量的监测确保只有“拟合”转录物退出核并被翻译，而RNA干扰依靠选择性mRNA转换依靠其生物学后果，而新颖的药物靶向mRNA衰减途径。 由于这些原因，mRNA的离职率吸引了生命科学各个领域的兴趣。 拟议的FASEB会议在集中于mRNA衰减方面是独一无二的，从而在不同的生物环境中探索了基于这种普遍过程的细胞和分子水平的机制。 拟议的会议特别值得注意的是吸引研究原核生物和真核生物的研究人员，并专注于RNA与衰减设备，翻译设备以及调节衰减的因素相互作用的机制。 会议的会议将解决针对mRNA 5'或3'末端及其亚细胞定位的衰减事件； RNA结合蛋白，小RNA和其他衰减因子中的结构/功能关系； mRNA衰变与翻译和转录过程的相互作用； RNA质量控制和相关的监管网络；以及mRNA衰减的临床和药物相关性。 预计会议上的演讲将包括几种关键结构和机制的首次公开披露，并为调节增长，发展和疾病的调节提供新颖的见解。 简而言之，会议将概述令人兴奋的领域的最新进展，并将推动其发展的下一个阶段。