A5157 AN OPEN-LABEL, DOSE-ESCALATION PILOT STUDY OF ACETYL-L-CARNITINE (AIDS)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 一项多中心、开放标签、为期24周的初步研究，采用剂量递增的乙酰化L肉碱治疗与双脱氧核苷相关的艾滋病毒感染者的远端对称性周围神经病。 每6周将获得一次Gracely疼痛等级评估和安全信息。在基线和24周时进行表皮内神经纤维和皮下脂肪组织活检。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A multicenter, open-label, 24-week pilot study with dose escalation of acetyl-L-carnitine (ALC) for the treatment of distal symmetric peripheral neuropathy (DSPN) associated with dideoxynucleosides in HIV-infected subjects. Gracely pain scale assessments and safety information will be obtained every 6 weeks. An intraepidermal nerve-fiber and subcutaneous adipose tissue biopsy will be obtained at baseline and 24 weeks.