A5157 AN OPEN-LABEL, DOSE-ESCALATION PILOT STUDY OF ACETYL-L-CARNITINE (AIDS)

A5157 乙酰左旋肉碱（艾滋病）的开放标签、剂量递增试点研究

• 批准号: 7605177
• 负责人: ANDREW RICHARD ZOLOPA
• 金额: $ 0.76万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605177
• 关键词: Acquired Immunodeficiency Syndrome; Adipose tissue; Biopsy; Computer Retrieval of Information on Scientific Projects Database; Dideoxynucleosides; Distal; Dose; Funding; Grant; Institution; Label; Levocarnitine Acetyl; Nerve Fibers; Pain; Peripheral Nervous System Diseases; Pilot Projects; Research; Research Personnel; Resources; Safety; Source; United States National Institutes of Health; Week; subcutaneous

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A multicenter, open-label, 24-week pilot study with dose escalation of acetyl-L-carnitine (ALC) for the treatment of distal symmetric peripheral neuropathy (DSPN) associated with dideoxynucleosides in HIV-infected subjects. Gracely pain scale assessments and safety information will be obtained every 6 weeks. An intraepidermal nerve-fiber and subcutaneous adipose tissue biopsy will be obtained at baseline and 24 weeks.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 一项多中心、开放标签、24周的先导性研究，乙酰-L-肉碱（ALC）剂量递增治疗HIV感染受试者中与双脱氧核苷相关的远端对称性周围神经病变（DSPN）。 Gracely疼痛量表评估和安全性信息将每6周获得一次。 将在基线和24周时获得表皮内神经纤维和皮下脂肪组织活检。