SYSTEMIC ENDOTHELIAL CONSEQUENCES OF PERIODONTAL DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 牙周病是一种细菌感染的牙周组织，可导致骨和牙齿的损失。当严重时，口腔中的局部感染可能会刺激因子释放到血液中，导致全身血管受损。为了支持这种可能性，最近的研究表明，牙周病患者有内皮细胞（血管细胞的内层）受损的迹象。这种效应可能部分解释了最近的研究表明，这些患者的心脏病发作和中风率较高。这项拟议的研究将确定是否更密集的治疗晚期牙周病（深度清洁和牙龈手术，在适当的情况下）改善内皮细胞的功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Periodontal disease is a bacterial infection of the periodontal tissues that may lead to bone and tooth loss. When severe, the local infection in the mouth may stimulate release of factors into the blood that cause damage to blood vessels throughout the body. In support of this possibility, recent studies show that patients with periodontal disease have signs of damage to the endothelium (inner lining of cells in blood vessels). This effect might explain, in part, recent studies showing higher rates of heart attack and stroke in such patients. The proposed study will determine whether more intensive treatment of advanced periodontal disease (deep cleaning and gum surgery where appropriate) improves the function of the endothelium.