RESIDUAL EFFECTS OF INTOXICATION ON STUDENT PERFORMANCE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目将从家长研究：醉酒对学生表现的残余影响(H-23064)中招募受试者。S项目的目标是利用神经成像数据，通过快速磁共振成像(FMRI)和磁共振波谱(MRS)测量，了解酒精中毒对大脑激活和神经化学的后遗症。在筛查面试后，受试者将被允许进入GCRC进行两次入院：一次是酒精剂量，另一次是安慰剂剂量。受试者已经通过了一次家长研究。受试者将在服药前进行基线成像，并在服药后第二天早上进行成像。所有的成像都将在波士顿大学医学中心的生物医学成像中心(CBI)进行。 将检验六个假设：1.连续操作任务的操作时间与任务期间激活的前额叶皮质面积呈负相关，由BOLD数据确定。2.以血流增加为指标的前额叶皮质激活面积最大的增加将出现在酒精后成像过程中。3.酒精挑战基础数据与激发后数据比较时，N-乙酰阿司匹林(NAA)降低，谷氨酸升高，γ-氨基丁酸(GABA)不变。4.NAA的变化与宿醉自评呈正相关。5.与非饮酒相比，饮酒后第二天早晨的一氧化氮水平会下降。6.与非饮酒相比，饮酒后第二天早上皮质醇水平会下降。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will recruit subjects from parent study: Residual Effects of Intoxication on Student Performance (H-23064). This project s goal is to use neuroimaging data to understand the aftereffects of alcohol intoxication on brain activation and neurochemistry as measured by fast magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS). After a screening interview, subjects will be admitted to the GCRC for two admissions: one with an alcohol dosing and one with a placebo dosing. Subjects will have already gone through the parent study once. Subjects will have a baseline imaging prior to dosing and a imaging the morning after dosing. All imaging will be at the Center for Biomedical Imaging (CBI) at Boston University Medical Center. Six hypotheses will be tested: 1.There will be a negative correlation between the performance time in continuous performance tasks and the amount of area of prefrontal cortex activated during the task as determined by the BOLD data. 2.The greatest increase in the area of the prefrontal cortex activated as measured by increased blood flow will be seen during the post-alcohol imaging session. 3.N-acetyl aspirate (NAA) will be reduced, glutamate will be increased and gamma aminobutyric acid (GABA) will be unchanged when comparing the baseline data to the post-challenge data in the alcohol challenge. 4.Changes in NAA will be positively correlated with self-reports of hangover. 5.Nitric oxide levels will decrease on the morning after alcohol dosing compared to non-alcohol dosing. 6. Cortisol levels will decrease on the morning after alcohol dosing compared to non-alcohol dosing.