YOGA INDUCED CHANGES IN BRAIN GABA LEVELS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这是一项试点研究，旨在为重新提交研究瑜伽练习对大脑γ-氨基丁酸（GABA）水平影响的拨款提供初步数据。我们已经完成了几项研究，表明与正常对照组相比，可卡因依赖者的GABA水平降低。这与文献显示大脑GABA水平在其他精神疾病如抑郁症和焦虑症中降低是一致的。虽然瑜伽可以增加大脑GABA水平，但我们没有任何试验数据支持这一说法。这项小型的试点研究旨在探索瑜伽练习对大脑GABA水平的影响，无论是在基线状态还是在10名瑜伽练习者进行一小时瑜伽练习后。我们将使用2D、J分辨GABA化学位移成像（CSI）扫描，在同一天获得两次扫描。第一次扫描将在基线，第二次扫描将在一小时的瑜伽练习后进行。将在姆克林医院进行扫描。我们的主要因变量将是大脑GABA水平。我们将测试以下假设：假设一：大脑中的GABA水平将更高的主题与一个既定的瑜伽练习相比，正常对照组和可卡因依赖的个人。我们将使用我们已经收集的对照组和可卡因依赖受试者的数据进行比较。 假设二：大脑中的GABA水平增加了一个小时的瑜伽课程后，建立了瑜伽练习的受试者，相比GABA水平在同一天前一个小时的瑜伽课程。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a pilot study designed to provide preliminary data for the resubmission of a grant looking at the effects of a yoga practice on brain gamma-amniobutryric acid (GABA) levels. We have completed several studies that have shown GABA levels to be decreased in cocaine dependent individuals compared to normal controls. This is consistent with the literature that shows brain GABA levels to be decreased in other psychiatric illness such as depression and anxiety disorders. Although a compelling argument can be made that yoga should increase brain GABA levels, we do not have any pilot data to support this claim. This small pilot study is to explore the effect of an established yoga practice on brain GABA levels, both at a baseline state and after a one-hour yoga practice in 10 established yoga practitioners. We will use 2D, J-resolved GABA Chemical Shift Imaging (CSI) scans to obtain two scans on the same day. The first scan will be at baseline and the second scan will be after a one-hour yoga practice. Scans will be obtained at the Mclean Hospital. Our primary dependent variable will be brain GABA levels. We will test the following hypothesis: Hypothesis I: Brain GABA levels will be higher in subjects with an established yoga practice compared to normal control and individuals with cocaine dependence. We will use the data we have already collected on the controls and cocaine dependent subjects for comparison. Hypothesis II: Brain GABA levels increase in subjects with an established yoga practice after a one hour yoga session, compared to GABA levels obtained on the same day prior to the one hour yoga session.