EFFECT OF CLARITHROMYCIN ON THE ORAL CLEARANCE OF BUSPIRONE IN PATIENTS WITH
EFFECT OF CLARITHROMYCIN ON THE ORAL CLEARANCE OF BUSPIRONE IN PATIENTS WITH
批准号:
7606442
负责人:
STEPHEN D HALL
金额:
$0.12万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-12-01 至 2007-11-30
关键词:
Anti-Anxiety AgentsBuspironeCYP3A4 geneCirrhosisClarithromycinComputer Retrieval of Information on Scientific Projects DatabaseDoseDrug KineticsExhibitsFundingGoalsGrantHepaticIndividualInstitutionIntestinesLabelOralPatientsPharmaceutical PreparationsRandomizedResearchResearch PersonnelResourcesRiskSourceTransjugular intrahepatic portosystemic shunt procedureUnited States National Institutes of Healthcytochrome P450 3Aenzyme activityhealthy volunteertreatment duration
中文摘要
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
在经颈静脉肝内门体分流术(TIPS)的肝硬变患者中,肠道细胞色素P3A活性明显降低。这些患者预计会面临由细胞色素P450(CYP)3A代谢的药物的过度药理作用的风险。丁螺环酮是一种广泛使用的抗焦虑药物,它高度依赖于CYP 3A酶的活性来消除。在肝硬变患者中,丁螺环酮的口服清除量显著降低,原因是肝脏细胞色素P3A酶活性降低。本研究的目的是通过对12名有TIPS的肝硬化症患者、12名肝硬化症患者和12名健康志愿者进行一项开放的随机研究,来表征口服丁螺环酮和克拉霉素治疗7天后的药代动力学变化。我们将比较三组患者服药后丁螺环酮AUC与服药前丁螺环酮AUC的比值所反映的相互作用程度。我们期望健康的志愿者和没有提示的肝硬化症患者将展示
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The intestinal CYP3A activity is markedly diminished in cirrhotics with transjugular intrahepatic portasystemic shunts (TIPS). These patients are expected to be at risk for excessive pharmacological effects of drugs that are metabolized by Cytochrome P450 (CYP) 3A. Buspirone is a widely used anxiolytic medication that is highly dependent on CYP 3A enzyme activity for elimination. The oral clearance of buspirone is significantly reduced in individuals with cirrhosis due to decrease in hepatic CYP3A enzyme activity. The goal of the current study is to characterize the change in the pharmacokinetics of orally administered buspirone with 7 day treatment of clarithromycin by conducting an open label, randomized study of 12 cirrhotics with TIPS, 12 cirrhotics and 12 healthy volunteers. We will compare the extent of interaction as reflected in the ratio of buspirone AUC following clarithromycin dosing to the buspirone AUC before clarithromycin dosing in the three groups. We expect that healthy volunteers and cirrhotics without TIPS will exhibit
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ONSET OF INHIBITORY EFFECT OF CLARITHROMYCIN ON HUMAN INTESTINAL CYTOCHROME P
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批准号:7717548
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项目类别:
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资助金额:$0.04万
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财政年份:2007
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负责人:STEPHEN D HALL
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依托单位:
THE DISPOSITION OF ACETAMINOPHEN AND FEXOFENADINE ALONE AND IN COMBINATION IN HE
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批准号:7717560
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项目类别:
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资助金额:$0.27万
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财政年份:2007
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负责人:STEPHEN D HALL
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依托单位:
THE EFFECT OF DOXYCYCLINE ON THE EFFICACY OF ORAL CONTRACEPTIVE PILLS
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批准号:7717515
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项目类别:
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资助金额:$0.15万
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财政年份:2007
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负责人:STEPHEN D HALL
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依托单位:
THE EFFECT OF CONCOMITANT ADMINISTRATION OF ERYTHROMYCIN AND DILTIAZEM ON CYP
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批准号:7717542
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项目类别:
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资助金额:$0.18万
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财政年份:2007
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负责人:STEPHEN D HALL
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依托单位:
EFFECT OF CLARITHROMYCIN ON THE ORAL CLEARANCE OF BUSPIRONE IN PATIENTS WITH
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批准号:7717539
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项目类别:
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资助金额:$0.01万
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财政年份:2007
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负责人:STEPHEN D HALL
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依托单位:
THE EFFECT OF DOXYCYCLINE ON THE EFFICACY OF ORAL CONTRACEPTIVE PILLS
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批准号:7606418
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项目类别:
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资助金额:$1.81万
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财政年份:2006
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负责人:STEPHEN D HALL
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依托单位:
THE DISPOSITION OF ACETAMINOPHEN AND FEXOFENADINE ALONE AND IN COMBINATION IN HE
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批准号:7606463
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项目类别:
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资助金额:$3.15万
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财政年份:2006
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负责人:STEPHEN D HALL
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依托单位:
ORAL ERYTHROMYCIN ON QT INTERVAL IN HEALTHY SUBJECTS, PATIENTS WITH CIRRHOSIS
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批准号:7606385
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项目类别:
-
资助金额:$0.27万
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财政年份:2006
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负责人:STEPHEN D HALL
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依托单位:
THE EFFECT OF CONCOMITANT ADMINISTRATION OF ERYTHROMYCIN AND DILTIAZEM ON CYP
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批准号:7606445
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项目类别:
-
资助金额:$2.09万
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财政年份:2006
-
负责人:STEPHEN D HALL
-
依托单位:
ONSET OF INHIBITORY EFFECT OF CLARITHROMYCIN ON HUMAN INTESTINAL CYTOCHROME P
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批准号:7606451
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项目类别:
-
资助金额:$0.5万
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财政年份:2006
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负责人:STEPHEN D HALL
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依托单位:
THE EFFECTS OF GENOTYPE ON DRUG RESPONSE
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批准号:7606387
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项目类别:
-
资助金额:$0.03万
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财政年份:2006
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负责人:STEPHEN D HALL
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依托单位:
EFFECT OF MULTIPLE DOSES OF KETOCONAZOLE ON CYTOCHROME P450 3A ACTIVITY
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批准号:7379103
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项目类别:
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资助金额:$1.68万
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财政年份:2005
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负责人:STEPHEN D HALL
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依托单位:
ONSET OF INHIBITORY EFFECT OF CLARITHROMYCIN ON HUMAN INTESTINAL CYTOCHROME P
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批准号:7379164
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项目类别:
-
资助金额:$0.89万
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财政年份:2005
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负责人:STEPHEN D HALL
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依托单位:
THE EFFECT OF ECHINACEA ON THE EFFICACY OF ORAL CONTRACEPTION
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批准号:7205784
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项目类别:
-
资助金额:$2.43万
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财政年份:2005
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负责人:STEPHEN D HALL
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依托单位:
THE EFFECT OF DOXYCYCLINE ON THE EFFICACY OF ORAL CONTRACEPTIVE PILLS
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批准号:7379113
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项目类别:
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资助金额:$3.03万
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财政年份:2005
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负责人:STEPHEN D HALL
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依托单位:
THE EFFECT OF DOXYCYCLINE ON THE EFFICACY OF ORAL CONTRACEPTIVE PILLS
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批准号:7205833
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项目类别:
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资助金额:$2.94万
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财政年份:2005
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负责人:STEPHEN D HALL
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依托单位:
RELATIONSHIP BETWEEN CYP3A5 GENOTYPES AND EFFECT OF VERAPAMIL ON MIDAZOLAM
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批准号:7379076
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项目类别:
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资助金额:$0.12万
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财政年份:2005
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负责人:STEPHEN D HALL
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依托单位:
RELATIONSHIP BETWEEN CYP3A5 GENOTYPES AND EFFECT OF VERAPAMIL ON MIDAZOLAM
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批准号:7205783
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项目类别:
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资助金额:$3.64万
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财政年份:2005
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负责人:STEPHEN D HALL
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依托单位:
THE EFFECTS OF GENOTYPE ON DRUG RESPONSE
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批准号:7205785
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项目类别:
-
资助金额:$0.07万
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财政年份:2005
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负责人:STEPHEN D HALL
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依托单位:
EFFECT OF MULTIPLE DOSES OF KETOCONAZOLE ON CYTOCHROME P450 3A ACTIVITY
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批准号:7205820
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项目类别:
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资助金额:$8.08万
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财政年份:2005
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负责人:STEPHEN D HALL
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依托单位:
海外基金