THE DISPOSITION OF ACETAMINOPHEN AND FEXOFENADINE ALONE AND IN COMBINATION IN HE

对乙酰氨基酚和非索非那定单独和组合在 HE 中的处置

• 批准号: 7717560
• 负责人: STEPHEN D HALL
• 金额: $ 0.27万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717560
• 关键词: Acetaminophen; Blood; Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; Hematologic Agents; Institution; Parents; Pharmaceutical Preparations; Randomized; Research; Research Personnel; Resources; Sampling; Source; United States National Institutes of Health; Urine; fexofenadine; healthy volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the proposed study is to determine whether the drugs acetaminophen and fexofenadine interact pharmacokinetically. Twenty healthy volunteers will receive acetaminophen and fexofenadine on separate occasions and together. The order of drug administration will be randomized. Serial blood and urine samples will be collected and analyzed for parent drug (blood and urine) and metabolites (urine). We anticipate a lack of interaction between these two compounds.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 拟议的研究的目的是确定对乙酰氨基酚和fexofenadine的药物是否相互作用。 二十名健康的志愿者将在不同的场合和共同的场合接受对乙酰氨基酚和fexofenadine。 药物管理顺序将随机分配。 将收集并分析系列血液和尿液样品中的母体药物（血液和尿液）和代谢产物（尿液）。 我们预计这两种化合物之间存在缺乏相互作用。