THE EFFECTS OF GENOTYPE ON DRUG RESPONSE

基因型对药物反应的影响

• 批准号: 7606387
• 负责人: STEPHEN D HALL
• 金额: $ 0.03万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606387
• 关键词: Clarithromycin; Code; Computer Retrieval of Information on Scientific Projects Database; Cytochrome P450; Cytochromes; Data; Drug Interactions; Drug Kinetics; Enzymes; Family; Funding; Genes; Genetic Variation; Genotype; Glycoproteins; Grant; Individual; Institution; Midazolam; Numbers; Pharmaceutical Preparations; Research; Research Personnel; Resources; Rifampin; Single Nucleotide Polymorphism; Source; United States National Institutes of Health; drug distribution; inhibitor/antagonist; response; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The majority of metabolized drugs are dependent on the cytochrome P450 family of enzymes for elimination from the body. In addition, ATP dependent transporters, such as p-glycoprotein, are also important determinants of drug distribution and elimination. Recent discoveries of single nucleotide polymorphisms in the genes that code for cytochrome P450s and drug transporters have suggested that genetic diversity contributes to interindividual variability in drug pharmacokinetics and response. We have previously obtained phenotypic data in a large number of volunteers and now propose to genotype these same individuals to reveal the contribution of genetic diversity to the pharmacokinetics of probe drugs, such as midazolam, and to drug-drug interactions with inhibitors and inducers, such as clarithromycin and rifampin.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 大多数代谢药物依赖于细胞色素P450酶家族从体内消除。 此外，ATP依赖性转运蛋白，如P-糖蛋白，也是药物分布和消除的重要决定因素。 最近发现的单核苷酸多态性的基因编码的细胞色素P450和药物转运蛋白表明，遗传多样性有助于个体间变异的药物药代动力学和响应。 我们以前已经获得了大量的志愿者的表型数据，现在建议对这些相同的个体进行基因分型，以揭示遗传多样性对探针药物（如咪达唑仑）的药代动力学以及与抑制剂和诱导剂（如克拉霉素和利福平）的药物相互作用的贡献。