THE DISPOSITION OF ACETAMINOPHEN AND FEXOFENADINE ALONE AND IN COMBINATION IN HE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项拟议研究的目标是确定对乙酰氨基酚和非索非那定是否存在药代动力学相互作用。20名健康志愿者将在不同的场合和一起接受扑热息痛和非索非那定的治疗。给药顺序将是随机的。将收集一系列的血液和尿液样本，并对母体药物(血液和尿液)和代谢物(尿液)进行分析。我们预计这两种化合物之间缺乏相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the proposed study is to determine whether the drugs acetaminophen and fexofenadine interact pharmacokinetically. Twenty healthy volunteers will receive acetaminophen and fexofenadine on separate occasions and together. The order of drug administration will be randomized. Serial blood and urine samples will be collected and analyzed for parent drug (blood and urine) and metabolites (urine). We anticipate a lack of interaction between these two compounds.