THE EFFECT OF DOXYCYCLINE ON THE EFFICACY OF ORAL CONTRACEPTIVE PILLS

强力霉素对口服避孕药疗效的影响

• 批准号: 7717515
• 负责人: STEPHEN D HALL
• 金额: $ 0.15万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717515
• 关键词: Anthrax disease; Antibiotics; Bioterrorism; Breakthrough Bleeding; Computer Retrieval of Information on Scientific Projects Database; Contraceptive Agents; Disease Outbreaks; Dose; Doxycycline; Drug Interactions; Drug Kinetics; Ethinyl Estradiol; Follicle Stimulating Hormone; Frequencies; Funding; Grant; Infection; Institution; Label; Long-Term Effects; Luteinizing Hormone; Oral; Oral Contraceptives; Ovulation; Plasma; Progesterone; Research; Research Personnel; Resources; Source; Steroids; Surrogate Markers; United States National Institutes of Health; contraceptive efficacy; indexing; interest; pill; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The drug interaction between oral contraceptives and oral antibiotics may reduce the exposure of the body to the contraceptive steroids leading to the legitimate concern that contraceptive efficacy may be reduced or lost. This potential for reduced efficacy has become more likely in recent years because of the lower recommended doses of oral contraceptives and the frequency with which antibiotics and oral contraceptives are co-prescribed. An interaction with doxycycline is of particular interest because of the expected widespread use of this antibiotic during an outbreak of anthrax infection following a bioterrorism attack. We plan to quantify the effect long-term doxycycline dosing on the pharmacokinetics ethinylestradiol and nonrethindrone and on the plasma concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH) and progesterone as surrogate markers of ovulation. The frequency of breakthrough bleeding will be determined as an additional index of oral contraceptive efficacy. This will be an open-label, fixed order, two-period (two cycle per period), study of 24 volunteers.

这个子项目是众多研究子项目之一