THE INFLUENCE OF ACUPUNCTURE ON REPRODUCTIVE HORMONES AND OVULATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 多囊卵巢综合征（PCOS）是导致月经不调和无排卵性不孕的最常见原因。针灸可能是这些妇女激素治疗的替代方案，基于三项研究，少于50名针灸受试者和无对照组的阳性结果。 这项研究将是一项双盲，安慰剂对照，随机临床试验，以评估针灸是否恢复排卵（2+排卵）并使PCOS女性的卵巢激素（促卵泡激素和促黄体激素）正常化。 这项研究将评估在我们的PCOS人群中针灸是否增加排卵频率，导致促黄体生成素（LH）与卵泡刺激素（FSH）的比例正常化，并导致FSH和LH的平均水平向正常水平调整（分别增加和减少）。我们还将比较招募策略（广播与电视等）为基础的人口招募妇女进入针灸临床试验。最后，我们将评价受试者对真实和假研究治疗的感知

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic Ovary Disease (PCOS) is the most common cause of irregular menstrual cycles and anovulatory infertility. Acupuncture may represent an alternative to hormonal treatment for these women, based on three studies with positive findings with fewer than 50 acupuncture subjects and no control group. The proposed research will be a double-blind, placebo-controlled, randomized clinical trial to assess if acupuncture restores ovulation (2+ ovulations) and normalizes ovarian hormones (follicle stimulating hormone and luteinizing hormone) in women with PCOS. This research will assess within our PCOS population whether acupuncture increases ovulatory frequency, causes the ratio of luteinizing hormone (LH) to follicle stimulating hormone (FSH) to normalize, and causes the average levels of FSH and LH to adjust towards normal levels (increase and decrease, respectively). We will also compare enrollment strategies (radio vs. TV, etc) for population-based recruitment of women into an acupuncture clinical trial. Lastly, we will evaluate participant perception of the true and sham study treatments