THE INFLUENCE OF ACUPUNCTURE ON REPRODUCTIVE HORMONES AND OVULATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 多囊卵巢疾病(PCOS)是导致月经周期不规律和无排卵性不孕的最常见原因。针灸可能是这些女性激素治疗的另一种选择，基于三项研究，这些研究的阳性结果是不到50名针灸受试者和没有对照组。这项拟议的研究将是一项双盲、安慰剂对照的随机临床试验，以评估针灸是否能恢复多囊卵巢综合征患者的排卵(两次排卵)并使卵巢激素(卵泡刺激素和黄体生成素)正常化。这项研究将在我们的PCOS人群中评估针灸是否增加排卵频率，使黄体生成素(LH)和卵泡刺激素(FSH)的比率正常化，并使FSH和LH的平均水平调整到正常水平(分别增加和减少)。我们还将比较针灸临床试验中基于人群招募女性的招募策略(广播与电视等)。最后，我们将评估参与者对真实和虚假研究治疗的感知。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic Ovary Disease (PCOS) is the most common cause of irregular menstrual cycles and anovulatory infertility. Acupuncture may represent an alternative to hormonal treatment for these women, based on three studies with positive findings with fewer than 50 acupuncture subjects and no control group. The proposed research will be a double-blind, placebo-controlled, randomized clinical trial to assess if acupuncture restores ovulation (2+ ovulations) and normalizes ovarian hormones (follicle stimulating hormone and luteinizing hormone) in women with PCOS. This research will assess within our PCOS population whether acupuncture increases ovulatory frequency, causes the ratio of luteinizing hormone (LH) to follicle stimulating hormone (FSH) to normalize, and causes the average levels of FSH and LH to adjust towards normal levels (increase and decrease, respectively). We will also compare enrollment strategies (radio vs. TV, etc) for population-based recruitment of women into an acupuncture clinical trial. Lastly, we will evaluate participant perception of the true and sham study treatments.