THE INFLUENCE OF ACUPUNCTURE ON REPRODUCTIVE HORMONES AND OVULATION

针灸对生殖激素和排卵的影响

• 批准号: 8167155
• 负责人: LISA M PASTORE
• 金额: $ 41.83万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167155
• 关键词: Acupuncture procedure; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Double-Blind Method; Enrollment; Follicle Stimulating Hormone; Frequencies; Funding; Grant; Hormonal; Infertility; Institution; Luteinizing Hormone; Menstrual cycle; Ovarian hormone; Ovulation; Participant; Perception; Placebo Control; Polycystic Ovary Syndrome; Population; Radio; Randomized Clinical Trials; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Woman; base; population based; reproductive hormone

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic Ovary Disease (PCOS) is the most common cause of irregular menstrual cycles and anovulatory infertility. Acupuncture may represent an alternative to hormonal treatment for these women, based on three studies with positive findings with fewer than 50 acupuncture subjects and no control group. The proposed research will be a double-blind, placebo-controlled, randomized clinical trial to assess if acupuncture restores ovulation (2+ ovulations) and normalizes ovarian hormones (follicle stimulating hormone and luteinizing hormone) in women with PCOS. This research will assess within our PCOS population whether acupuncture increases ovulatory frequency, causes the ratio of luteinizing hormone (LH) to follicle stimulating hormone (FSH) to normalize, and causes the average levels of FSH and LH to adjust towards normal levels (increase and decrease, respectively). We will also compare enrollment strategies (radio vs. TV, etc) for population-based recruitment of women into an acupuncture clinical trial. Lastly, we will evaluate participant perception of the true and sham study treatments.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 多囊卵巢病（PCOS）是月经周期不规律和无排卵性不孕的最常见原因。根据三项研究的积极结果，针灸可能是这些女性荷尔蒙治疗的替代方案，其中少于 50 名针灸受试者且没有对照组。 拟议的研究将是一项双盲、安慰剂对照、随机临床试验，旨在评估针灸是否可以恢复 PCOS 女性的排卵（2+排卵）并使卵巢激素（卵泡刺激素和黄体生成素）正常化。 这项研究将在我们的 PCOS 人群中评估针灸是否会增加排卵频率，导致黄体生成素 (LH) 与卵泡刺激素 (FSH) 的比例正常化，并导致 FSH 和 LH 的平均水平调整至正常水平（分别增加和减少）。我们还将比较基于人群招募女性参加针灸临床试验的招募策略（广播与电视等）。最后，我们将评估参与者对真实和虚假研究治疗的看法。