CORONARY ARTERY DISEASE AND INSULIN RESISTANCE IN MEXICAN AMERICAN

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of project 1 is to intensively phenotype Mexican American (MA) families which have been ascertasined via an index case with coronary artery disease (CAD) in order to investigate physiologic and genetic interrelations between insulin resistance (IR), the insulin resistance syndrome, and athersclerosis. We hypothize that there is a strong basis for IR, components of the metabolic syndrome, and CAD, and that IR and the metabolic syndrome are major contributing factors to CAD in MA.