ENERGY EXPENDITURE IN INFANTS WITH HYPOPLASTIC LEFT HEART SYNDROME

左心发育不全综合征婴儿的能量消耗

• 批准号: 7606486
• 负责人: Scott C. Denne
• 金额: $ 0.16万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606486
• 关键词: Common Ventricle; Computer Retrieval of Information on Scientific Projects Database; Cyanosis; Energy Intake; Energy Metabolism; Funding; Grant; Growth; Hypoplastic Left Heart Syndrome; Infant; Institution; Knowledge; Lesion; Metabolic; Nutritional Requirements; Nutritional Support; Operative Surgical Procedures; Patients; Physiology; Population; Procedures; Purpose; Rate; Reflux; Research; Research Personnel; Resources; Rest; Source; Staging; Time; Tricuspid valve structure; United States National Institutes of Health; congenital heart disorder; experience; healthy aging; improved; repaired

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infants with congenital heart disease frequently experience growth retardation. Several factors may contribute to this growth retardation, including increased metabolic rate and decreased caloric intake. The purpose of the proposed research is to determine the effect of single ventricle physiology (hypoplastic left heart syndrome or HLHS) and cyanosis on total and resting energy expenditure and caloric intake in a group of 3-4 month old infants and group of healthy age-matched controls. We have restricted our patient population to those infants with isolated HLHS so as to examine the effect of only this lesion without complications arising from other factors. We will study those patients who have undergone Stage 1 Norwood procedure, which is the first of three surgical stages to full repair. The patient group will be subdivided as to whether the infant has minimal or significant tricuspid valve reflux. Knowledge of the energy expenditures of these patients is necessary to accurately gauge their energy requirements, provide optimal nutritional support and optimize the timing of surgical correction. Survival of the infants to the next stage of surgical repair may be improved by optimizing nutritional requirements.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 先天性心脏病的婴儿经常会出现迟钝。几个因素可能会导致这种增长迟钝，包括增加代谢率和降低热量摄入量。拟议的研究的目的是确定单个心室生理学（左心脏综合征或HLHS）和氰化物的影响对一组3-4个月大的婴儿以及一组健康年龄匹配的对照组中的总能量消耗和热量摄入。我们将患者人群限制在患有孤立的HLHS的婴儿中，以便检查这种病变的作用，而没有其他因素引起的并发症。我们将研究那些接受过1阶段诺伍德手术的患者，这是三个手术阶段中的第一个进行全面修复。患者组将被细分为婴儿是最小还是显着的三尖瓣反流。必须了解这些患者的能量支出，对于准确评估其能量需求，提供最佳的营养支持并优化手术矫正时机是必要的。通过优化营养需求，可以改善婴儿到下一阶段的手术​​修复阶段的生存。