ENDOTHELIAL DYSFUNCTION IN TERM AND NEAR-TERM NEONATES WITH PULMONARY HYPERTENS

患有肺动脉高压的足月和近足月新生儿的内皮功能障碍

• 批准号: 7606488
• 负责人: Scott C. Denne
• 金额: $ 0.72万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606488
• 关键词: Animals; Computer Retrieval of Information on Scientific Projects Database; Functional disorder; Funding; Grant; Infant; Institution; Knowledge; Lung; Morbidity - disease rate; Persistent Fetal Circulation Syndrome; Play; Purpose; Research; Research Personnel; Resources; Role; Source; Techniques; United States National Institutes of Health; experience; mortality; neonatal pulmonary hypertension; neonate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Persistent pulmonary hypertension of the newborn (PPHN) is an important cause of morbidity and mortality in term and near-term infants. There is accumulating evidence, largely from animal studies, that abnormalities of endothelial function may play a role in PPHN. To our knowledge, there is no information specifically assessing endothelial function in neonates who have experienced PPHN. The purpose of this study is to provide preliminary information about possible endothelial dysfunction in PPHN using a noninvasive technique.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 新生儿（PPHN）的持续性肺动脉高压是期限和近期婴儿发病率和死亡率的重要原因。 积累的证据很大程度上来自动物研究，表明内皮功能的异常可能在PPHN中起作用。 据我们所知，没有信息专门评估经历了PPHN的新生儿的内皮功能。 这项研究的目的是使用无创技术提供有关PPHN可能内皮功能障碍的初步信息。