EXHALED NITRIC OXIDE IN ACUTE ASTHMA

急性哮喘中呼出的一氧化氮

• 批准号: 7606643
• 负责人: CHRISTINA DANELL SCHWINDT
• 金额: $ 0.33万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606643
• 关键词: Accident and Emergency department; Acute; Affect; Air; Asthma; Breathing; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Devices; Disease; Effectiveness; Exhalation; Funding; Grant; Inflammation; Institution; Light; Lung; Measures; Modeling; Monitor; Muscle; Nitric Oxide; Ozone; Patients; Purpose; Research; Research Personnel; Resources; Sampling; Source; Structure of parenchyma of lung; Swelling; Travel; Tube; United States National Institutes of Health; airway inflammation; chemical reaction; experience; indexing; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma is a disease that affects the airways (tubes that carry air in and out of the lungs). In an asthma attack, muscles around the airways constrict (tighten up), making the airway openings narrower and limiting the air flow to the lung tissues. Inflammation (swelling) increases and the airways become narrower, making breathing difficult. Studies have shown that nitric oxide (NO), a marker of airway inflammation, is increased in the breath of people experiencing an asthma attack. We hypothesize that asthma treatment administered during an attack may cause a decrease in the exhaled NO concentration of asthmatics by reducing the amount of inflammation in the lungs and that these changes in exhaled NO levels may be useful indicators in assessing the effectiveness of the asthma treatment. The purpose of this research study is to determine the effects of asthma treatment on the exhaled NO concentration of patients who are receiving treatment in the emergency room (ER) for an asthma attack and whether measuring these changes in exhaled NO levels may be used to monitor their response to the treatment. By better defining this relationship, exhaled NO levels may be used as a potential noninvasive clinical index for discharging asthma patients from the ER. Exhaled nitric oxide will be measured using a fast-response chemiluminescence analyzer (Sievers Model 280 Nitric Oxide Analyzer). The analyzer will be connected by a breathing tube to a mouthpiece which will be used to collect exhaled breath samples from subjects. As subjects slowly exhale into the mouthpiece, their exhaled breath will travel through the breathing tube and into the analyzer, which will measure the concentration of NO in the exhaled air by analyzing the light emitted from the chemical reaction of the exhaled air with ozone. The device, currently located at UCIMC's General Clinical Research Center, sits on a wheeled cart and is portable. When in use during the study, it will be kept in the ED.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 哮喘是一种影响呼吸道的疾病（将空气送入和送出肺部的管道）。 在哮喘发作时，气道周围的肌肉收缩（收紧），使气道开口变窄，限制空气流向肺组织。 炎症（肿胀）增加，气道变窄，使呼吸困难。 研究表明，一氧化氮（NO），气道炎症的标志物，在经历哮喘发作的人的呼吸中增加。 我们假设，哮喘发作期间给予治疗可能会导致减少呼出的NO浓度的哮喘患者减少肺部炎症的量，呼出的NO水平的这些变化可能是有用的指标，在评估哮喘治疗的有效性。 本研究的目的是确定哮喘治疗对在急诊室（ER）接受哮喘发作治疗的患者呼出NO浓度的影响，以及测量呼出NO水平的这些变化是否可用于监测他们对治疗的反应。 通过更好地定义这种关系，呼出的NO水平可以作为一个潜在的非侵入性的临床指标，从ER哮喘患者出院。 使用快速响应化学发光分析仪（Sievers 280型一氧化氮分析仪）测量呼出的一氧化氮。 分析仪将通过呼吸管连接到吸嘴，吸嘴将用于采集受试者的呼出气样本。 当受试者慢慢地向吸嘴呼气时，他们呼出的气体将通过呼吸管进入分析仪，分析仪将通过分析呼出空气与臭氧的化学反应发出的光来测量呼出空气中的NO浓度。 该设备目前位于UCIMC的综合临床研究中心，位于一个轮式推车上，是便携式的。 研究期间使用时，将保存在ED。