THE EFFECTS OF INHALED CORTICOSTEROIDS ON THE PERIPHERAL BLOOD IMMUNE SYSTEM OF
吸入皮质类固醇对外周血免疫系统的影响
基本信息
- 批准号:7725043
- 负责人:
- 金额:$ 0.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-12-01 至 2008-11-30
- 项目状态:已结题
- 来源:
- 关键词:Adrenal Cortex HormonesAdultBasophilsBloodBreathingCD19 geneCD3 AntigensCD8B1 geneCell Adhesion MoleculesCell surfaceCellsComputer Retrieval of Information on Scientific Projects DatabaseExerciseFloventFundingGrantImmune systemImmunityInflammationInflammatoryInstitutionInterferonsInterleukin-10Interleukin-4Interleukin-5Interleukin-6InvestigationLeukocytesLymphocyteMediatingMediator of activation proteinPeripheralPilot ProjectsProductionProteinsPurposeResearchResearch PersonnelResourcesSourceSteroidsUnited States National Institutes of Healthcytokinedayeosinophilfluticasonelymphocyte proliferationmalemonocyteneutrophilperipheral bloodresponse
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Purpose: This investigation is a pilot study to assess the effect of inhaled corticosteroids (ICS) on peripheral blood inflammatory cells and mediators. Specifically, we will look at white blood cells (neutrophils, lymphocytes, monocytes, eosinophils, and basophils), lymphocyte cell surface markers (markers that identify the different lymphocytes), cytokines (small secreted proteins from white blood cells which mediate and regulate immunity and inflammation), and lymphocyte proliferation in the peripheral blood of healthy adult males. These results will be correlated to the concentration of the steroid in the blood. We will use exercise, a robust stimulant of the immune system, as a means of detecting alterations and modulation of the peripheral immune system.
We propose to evaluate the following changes in the peripheral blood of healthy adult males in response to exercise after a 14 day course of ICS:
Specific Aim 1: The change in the peripheral white blood cells (neutrophils, lymphocytes, monocytes, eosinophils, and basophils).
Specific Aim 2: The change in inflammatory markers, including lymphocyte cell surfaces markers (including CD3+, CD4+, CD8+, CD4+CD25+, CD4+CD45RO+RA+, CD19+, and CD16/65), cytokine production [interleukin (IL)-4, IL-5, IL-6, IL-10, interferon (IFN)-?, and soluble intracellular adhesion molecule (sICAM)], and lymphocyte proliferation.
Specific Aim 3: To correlate the change in inflammatory markers in relation to concentration levels of Fluticasone (Flovent).
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
目的:本研究是一项初步研究,以评估吸入皮质类固醇(ICS)对外周血炎症细胞和介质的影响。 具体而言,我们将观察健康成年男性外周血中的白色血细胞(中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞和嗜碱性粒细胞)、淋巴细胞表面标志物(识别不同淋巴细胞的标志物)、细胞因子(来自白色血细胞的小分泌蛋白,介导和调节免疫和炎症)和淋巴细胞增殖。 这些结果将与血液中类固醇的浓度相关。 我们将使用运动,免疫系统的强大刺激剂,作为检测外周免疫系统的改变和调节的手段。
我们建议评估健康成年男性在接受14天ICS疗程后,外周血对运动反应的以下变化:
具体目的1:外周白色血细胞(中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞和嗜碱性粒细胞)的变化。
具体目标二:炎症标志物的变化,包括淋巴细胞表面标志物(包括CD 3+、CD 4+、CD 8+、CD 4 + CD 25+、CD 4 + CD 45 RO +RA+、CD 19+和CD 16/65)、细胞因子产生[白细胞介素(IL)-4,IL-5,IL-6,IL-10,干扰素(IFN)-?,和可溶性细胞内粘附分子(sICAM)]和淋巴细胞增殖。
具体目标3:将炎症标志物的变化与氟替卡松(Flovent)的浓度水平相关联。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CHRISTINA DANELL SCHWINDT其他文献
CHRISTINA DANELL SCHWINDT的其他文献
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{{ truncateString('CHRISTINA DANELL SCHWINDT', 18)}}的其他基金
THE EFFECTS OF INHALED CORTICOSTEROIDS ON THE PERIPHERAL BLOOD IMMUNE SYSTEM OF
吸入皮质类固醇对外周血免疫系统的影响
- 批准号:
8166917 - 财政年份:2009
- 资助金额:
$ 0.78万 - 项目类别:
THE EFFECTS OF INHALED CORTICOSTEROIDS ON THE PERIPHERAL BLOOD IMMUNE SYSTEM OF
吸入皮质类固醇对外周血免疫系统的影响
- 批准号:
7951060 - 财政年份:2008
- 资助金额:
$ 0.78万 - 项目类别:
Exercise, Pollution, and Neutrophils in Pediatric Asthma
运动、污染和中性粒细胞与小儿哮喘的关系
- 批准号:
7531043 - 财政年份:2006
- 资助金额:
$ 0.78万 - 项目类别:
Exercise, Pollution, and Neutrophils in Pediatric Asthma
运动、污染和中性粒细胞与小儿哮喘的关系
- 批准号:
7743092 - 财政年份:2006
- 资助金额:
$ 0.78万 - 项目类别:
Exercise, Pollution and Neutrophils in Pediatric Asthma
运动、污染和中性粒细胞在小儿哮喘中的作用
- 批准号:
7324078 - 财政年份:2006
- 资助金额:
$ 0.78万 - 项目类别:
Exercise, Pollution, and Neutrophils in Pediatric Asthma
运动、污染和中性粒细胞与小儿哮喘的关系
- 批准号:
7036951 - 财政年份:2006
- 资助金额:
$ 0.78万 - 项目类别:
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