THE EFFECTS OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV damages the immune system by infecting many different types of blood cells in the body. Some of the infected cells are supposed to protect the body from disease by helping to fight infections, such as HIV. When these cells become infected, they are not able to fight infections and eventually the cells die. As a result, a child's immune system gets weak. When a child takes a combination of drugs for the treatment of HIV infection (HAART), the virus is not able to multiple as quickly and the cells of the immune system can help fight infection. The purpose of this study is to tell how many immune cells return, and the amount of HIV in the blood while he/she is on HAART. In order to study a child's immune system, he/she will receive two different vaccines which are approved by the FDA for children.