IMMUNOLOGIC MEMORY FOLLOWING PNEUMOCOCCAL, HEP B, AND MEASLES VACCINATION P1061

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This subject is eligible to participate in this substudy because they have participated in P1024, "Evaluation of the Immunogenicity of Pneumococcal Conjugate Vaccine and Routine Pediatric Immunizations in HIV-Infected Children Treated with Highly Active Antiretroviral Therapy (HAART)." P1024 was a study to see how well the following vaccines can help children fight different types of infection: Pneumococcal Conjugate Vaccine (PCV), Pneumococcal Polysaccharide Vaccine (PPV), Measles-Mumps-Rubella Vaccine (M-M-R¿II), Diphtheria-Tetanus-Pertussis Vaccine (DTaP) and Hepatitis B Vaccine (HBV). This substudy will look at whether or not the subject has developed "immunologic memory" from the vaccines received in P1024 . To see if they have developed protective cells that remember how to fight pneumococcal, measles, and hepatitis B infection). This substudy will check if they are still protected from the following: pneumococcal infection, measles, and/or hepatitis B virus. This substudy will not look at immunologic protection against pertussis. This substudy will look at whether the subject has developed protective cells that remember how to fight pneumococcal, measles, and hepatitis B infection by giving you/your child additional (booster) doses of Pneumococcal Conjugate Vaccine (PCV) or Pneumococcal Polysaccharide Vaccine (PPV); Measles-Mumps-Rubella Vaccine (M-M-R¿II); and Hepatitis B Vaccine (HBV) and looking at blood tests that test for responses to these vaccines. The child will not receive a booster dose of Diphtheria-Tetanus-Pertussis Vaccine (DTaP) as part of this substudy.