IMMUNOLOGIC MEMORY FOLLOWING PNEUMOCOCCAL, HEP B, AND MEASLES VACCINATION P1061

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该受试者有资格参加该子研究，因为他们参加了P1024，“在接受高效抗逆转录病毒治疗（HAART）的HIV感染儿童中评价肺炎球菌结合疫苗和常规儿科免疫接种的免疫原性”。“P1024是一项研究，目的是探讨以下疫苗对儿童对抗不同类型感染的效用：肺炎球菌结合疫苗、肺炎球菌多糖疫苗、麻疹-流行性腮腺炎-风疹疫苗、白喉-破伤风-百日咳疫苗及B型肝炎疫苗。 该子研究将观察受试者是否对P1024中接受的疫苗产生了“免疫记忆”。看看他们是否已经形成了保护性细胞，记住如何对抗肺炎球菌，麻疹和肝炎B感染）。 该子研究将检查他们是否仍然受到以下保护：肺炎球菌感染、麻疹和/或B型肝炎病毒。 这个子研究将不关注对百日咳的免疫保护。 本子研究将观察受试者是否已形成保护性细胞，这些细胞可记住如何通过给予您/您的孩子额外（加强）剂量的肺炎球菌结合疫苗（PCV）或肺炎球菌多糖疫苗（PPV）、麻疹-腮腺炎-风疹疫苗（MRV）来对抗肺炎球菌、麻疹和B型肝炎感染。（M-M-R <$II）;和B肝炎疫苗（HBV），并期待血液测试，测试对这些疫苗的反应。 作为本次子研究的一部分，儿童将不接受白喉-破伤风-百日咳疫苗（DTaP）的加强剂量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This subject is eligible to participate in this substudy because they have participated in P1024, "Evaluation of the Immunogenicity of Pneumococcal Conjugate Vaccine and Routine Pediatric Immunizations in HIV-Infected Children Treated with Highly Active Antiretroviral Therapy (HAART)." P1024 was a study to see how well the following vaccines can help children fight different types of infection: Pneumococcal Conjugate Vaccine (PCV), Pneumococcal Polysaccharide Vaccine (PPV), Measles-Mumps-Rubella Vaccine (M-M-R¿II), Diphtheria-Tetanus-Pertussis Vaccine (DTaP) and Hepatitis B Vaccine (HBV). This substudy will look at whether or not the subject has developed "immunologic memory" from the vaccines received in P1024 . To see if they have developed protective cells that remember how to fight pneumococcal, measles, and hepatitis B infection). This substudy will check if they are still protected from the following: pneumococcal infection, measles, and/or hepatitis B virus. This substudy will not look at immunologic protection against pertussis. This substudy will look at whether the subject has developed protective cells that remember how to fight pneumococcal, measles, and hepatitis B infection by giving you/your child additional (booster) doses of Pneumococcal Conjugate Vaccine (PCV) or Pneumococcal Polysaccharide Vaccine (PPV); Measles-Mumps-Rubella Vaccine (M-M-R¿II); and Hepatitis B Vaccine (HBV) and looking at blood tests that test for responses to these vaccines. The child will not receive a booster dose of Diphtheria-Tetanus-Pertussis Vaccine (DTaP) as part of this substudy.