MRI/MRS INVESTIGATION OF YOUNG OFFSPRING OF BIPOLAR DISORDER PATIENTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究将通过调查双相患者的年轻双相患者后代可能存在的大脑异常来研究双相情感障碍的神经生物学，这些双相情感障碍患者患有双相情感障碍的风险很高。研究人员将获得3D MRI扫描和MRS扫描，以测量大脑NAA和肌醇水平。 该方案旨在招募和扫描20名没有精神障碍的双相情感障碍子女(未受影响的双相情感障碍子女)、20名患有双相情感障碍的双相情感障碍子女(受影响的双相情感障碍子女)、20名未受双相情感障碍影响但患有其他精神障碍的双相情感障碍子女(未受影响的双相情感障碍子女有其他精神障碍)，以及20名没有精神障碍家族史的健康对照组。 受试者将接受MRI/MRS扫描(1小时)、神经心理测试和常规实验室(CBC、肝功能测试、电解质、肾功能测试、甲状腺功能测试、血液化学、皮质醇水平、尿检、尿孕测试和尿药筛查)，以排除医疗问题、怀孕和药物使用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will examine the neurobiology of bipolar disorder by investigating possible brain abnormalities that could be present in young bipolar offspring of bipolar patients who are at high risk for developing bipolar disorder. The investigators will obtain 3D MRI scans and MRS scans to measure brain NAA and myo-inositol levels. The protocol is designed to enroll and scan 20 bipolar offspring who have no psychiatric disorder (unaffected bipolar offspring), 20 bipolar offspring with bipolar disorder (affected bipolar offspring with bipolar disorder), 20 bipolar offspring unaffected with bipolar disorder but affected with other psychiatric disorders (unaffected bipolar offspring with other psychiatric disorders), and 20 healthy controls with no familial history of psychiatric disorders. Subjects will have a MRI/MRS scan (1 hr), neuropsychological testing, and routine labs (CBC, liver function tests, electrolytes, kidney function tests, thyroid function test, blood chemistry, cortisol blood level, urinalysis, urine pregnancy test, and urine drug screen) to rule out medical problems, pregnancy, and drug use.