BRAIN CONECTIONS

大脑连接

• 批准号: 7627510
• 负责人: ROBIN L BREY
• 金额: $ 1.08万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627510
• 关键词: American College of Radiology; Antiphospholipid Antibodies; Blood specimen; Brain; Brain imaging; Cell Adhesion Molecules; Computer Retrieval of Information on Scientific Projects Database; Condition; DNA; Diagnosis; Disease; Disease Outcome; Education; Equipment and supply inventories; Ethnic Origin; Fibromyalgia; Funding; Gadolinium; Grant; Image; Imaging Techniques; Impaired cognition; Institution; Magnetic Resonance Imaging; Measures; Mental Depression; Morbidity - disease rate; Neuropsychological Tests; Newly Diagnosed; Numbers; Outcome; Pain; Pathogenesis; Patients; Physicians; Plasma; Predictive Value; Race; Research; Research Personnel; Resources; Serological; Socioeconomic Status; Source; Standards of Weights and Measures; Syndrome; Systemic Lupus Erythematosus; Therapeutic; Time; United States National Institutes of Health; Visit; clinically relevant; cognitive function; cytokine; fluorodeoxyglucose positron emission tomography; neuroimaging; neuropsychiatry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVES: The three specific aims of this study are 1) to determine the change in continuous measures of cognitive function over time among patients with a recent diagnosis of SLE; 2) to determine the predictive value of neuroimaging for decline in continuous measures of cognitive function in newly diagnosed SLE patients; 3) to determine the predictive value of serologic factors for decline in continuous measures of cognitive function in newly diagnosed SLE patients. METHODS: Thirty patients will undergo a baseline MRI with gadolinium and brain FDG PET, standard neuropsychological testing, disease activity will be assessed by the physician, and a blood sample will be taken. There will be quarterly visits for 3 1/2 to 4 years, depending on entry time. At each visit, the following will be repeated: disease activity measures, serum, plasma, and DNA storage, ANAM, depression inventory, fibromyalgia tender points, AIMS pain scale and ACR NPSLE case definitions. EXPECTED OUTCOME: We hope to find a moderate to severe decline in a clinically relevant number of newly diagnosed SLE patients using continuous measures of cognitive function independent of race, education, socioeconomic status and co-morbid conditions; imaging abnormalities will be more common in cognitively impaired subjects; and abnormalities observed in levels of Antiphospholipid antibodies, cytokines and soluble adhesion molecules will be associated with poorer cognitive function. CLINICAL RELEVANCE: Neuropsychiatric manifestations of Systemic Lupus Erythematosus (NPSLE) are both common and an important source of morbidity. Of the case definitions for NPSLE syndromes that have recently been developed, cognitive dysfunction appears to be the most prevalent. Little is know about the influence of co-morbidities or ethnicity/race on disease outcomes or the underlying pathogenesis of this important NPSLE syndrome. Perhaps most importantly, no rational therapeutic approach for the treatment of SLE-related cognitive dysfunction currently exists and is unlikely to be developed without a better understanding of neuropathological mechanisms. New brain imaging techniques using both structural and functional analyses have the potential to uncover mechanisms underlying NPSLE syndrome, particularly if specific syndromes are targeted.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：本研究的三个具体目的是：1)确定新近诊断的SLE患者认知功能连续指标随时间的变化；2)确定神经影像对新诊断SLE患者认知功能连续指标下降的预测价值；3)确定血清学因素对新诊断SLE患者认知功能连续指标下降的预测价值。 方法：30例患者将接受Gd和脑FDG PET的基线MRI检查，进行标准的神经心理测试，由医生评估疾病的活动性，并采集血样。根据参赛时间的不同，将在三年半至四年内每季度访问一次。在每次就诊时，将重复以下内容：疾病活动性测量、血清、血浆和DNA存储、ANAM、抑郁症清单、纤维肌痛压痛点、AIMS疼痛评分和ACR NPSLE病例定义。 预期结果：我们希望使用与种族、教育、社会经济地位和合并症无关的认知功能连续测量方法，发现临床上相关的新诊断SLE患者数量出现中度至严重下降；成像异常将在认知受损的受试者中更为常见；在抗磷脂抗体、细胞因子和可溶性黏附分子水平观察到的异常将与较差的认知功能相关。 临床意义：系统性红斑狼疮(NPSLE)的神经精神症状很常见，也是发病率的重要来源。在最近开发的NPSLE综合征的病例定义中，认知功能障碍似乎是最普遍的。关于这一重要的NPSLE综合征的共病或种族/种族对疾病结局或潜在发病机制的影响，人们知之甚少。也许最重要的是，目前还没有合理的治疗方法来治疗SLE相关的认知功能障碍，如果不能更好地了解神经病理机制，也不太可能开发出这种方法。使用结构和功能分析的新的脑成像技术有可能揭示NPSLE综合征的潜在机制，特别是如果特定的综合征是有针对性的。