MECHANISMS OF NO-CONTRIBUTION TO REFLEX CUTANEOUS VASODILATION WITH HYPERTENSIO

高血压对反射性皮肤血管舒张无贡献的机制

• 批准号: 7625829
• 负责人: LACY HOLOWATZ
• 金额: $ 2.83万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7625829
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Cutaneous; Funding; Grant; Institution; Purpose; Reactive Oxygen Species; Reflex action; Relative (related person); Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; Vasodilation; aged; arginase; healthy aging; human subject; human very old age (85+)

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the study is to determine the role of arginase in reflex cutaneous vasodilation in a healthy aged human subject group (65-85 years old) compared to a healthy young subject group (18-30 years old) and to examine the relative role of reactive oxygen species on the NO-dependent portion of reflex cutaneous vasodilation in an aged humans subject group compared to a healthy young subject group.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是确定与健康年轻受试者组（18-30岁）相比，在健康老年人受试者组（65-85岁）中，活性氧在反射性皮肤血管舒张中的作用，并检查与健康年轻受试者组相比，在老年人受试者组中，活性氧在反射性皮肤血管舒张的NO依赖性部分中的相对作用。