HYPERCHOLESTEROLEMIA AND HUMAN SKIN BLOOD FLOW

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 高胆固醇血症是动脉粥样硬化的危险因素。 通过促进血管舒张（VD）保护脉管系统的内皮一氧化氮（NO）的损失与增加的氧化应激相结合，与全身性血管功能障碍相关。 可能的机制1）增加血管平滑肌细胞的活性和2）内皮型一氧化氮合酶（eNOS）的“解偶联”有助于氧化应激。 我们在体内（皮内微透析）和体外实验（皮肤活检）检查机制，高胆固醇血症（HC）和年龄匹配的非高胆固醇血症（NC）进行比较。 我们研究用羟甲基戊二酰（HMG）CoA还原酶抑制剂降低胆固醇。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypercholesterolemia is a risk factor for atherosclerosis. Loss of endothelial nitric oxide (NO) which protects the vasculature through promoting vasodilation (VD) coupled with increased oxidative stress is associated with systemic vascular dysfunction. Possible mechanisms 1) increased vascular arginase activity and 2) endothelial nitric oxide synthase (eNOS) "uncoupling" contributing to oxidative stress. We pair in vivo (intradermal microdialysis) and in vitro experiments (skin biopsy) examining mechanisms in hypercholesterolemics (HC) and comparing with age-matched non-hypercholesterolemics (NC). We investigate reducing cholesterol with a hydroxymethylglutaryl (HMG) CoA reductase inhibitor.