THE ROLE OF NEURAL STEM CELLS IN THE DEVELOPMENT OF HUMAN EPILEPSY

神经干细胞在人类癫痫发展中的作用

• 批准号: 7607925
• 负责人: Weiming Xia
• 金额: $ 0.07万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-23 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607925
• 关键词: Affect; Animal Model; Behavioral; Biological Markers; Brain; Cell Proliferation; Childhood; Cognition; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Condition; Development; Epilepsy; Frequencies; Funding; Goals; Grant; Human; Human Development; Impairment; Institution; Intractable Epilepsy; Lead; Learning; Magnetic Resonance Spectroscopy; Medical; Metabolic; Motor Seizures; Neurologic; Numbers; Occupations; Patients; Process; Protons; Quality of life; Recurrence; Research; Research Personnel; Resolution; Resources; Role; Seizures; Site; Source; Temporal Lobe; Temporal Lobe Epilepsy; Time; United States National Institutes of Health; biological research; day; experience; in vivo; nerve stem cell; nervous system disorder; neuropsychological

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this proposal is to determine the role of active neural stem cell (NSC) proliferation in development of recurrent seizures and neurological, cognitive, and behavioral impairments in patients following a prolonged seizure. Seizure is one of the most common neurological disorders. A substantial number of patients who experience a seizure demonstrate progressively increased seizure frequency, and nearly half of all patients eventually develop epilepsy, a pathological condition of spontaneous recurring seizures despite optimal medical therapy. Patients with epilepsy often experience significant neuropsychological impairments, affecting their learning, job opportunities, and quality of life. This is particularly evident in childhood onset epilepsy. Despite extensive research, the biological mechanisms that lead to long-term alterations in cognition and sometimes progression to medically intractable seizures are still poorly understood. The most common site for the development of severe intractable epilepsy is located in the temporal lobe. Several studies in animal models of temporal lobe epilepsy have revealed significant activation of NSC within 3-7 days after a prolonged convulsive seizure. This process could not be studied in patients with epilepsy as, up to now, there have been no reliable biological markers to trace the fate of human NSC in vivo. Recently, a metabolic biomarker of NSC has been identified by Dr. Savatic, which enables us to investigate, for the first time, the fate of NSC in the human brain after a seizure, using noninvasive, high-resolution proton Magnetic Resonance Spectroscopy (1HMRS).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本提案的目标是确定活性神经干细胞（NSC）增殖在长期癫痫发作后患者复发性癫痫发作和神经，认知和行为障碍的发展中的作用。癫痫是最常见的神经系统疾病之一。大量经历癫痫发作的患者表现出癫痫发作频率逐渐增加，并且几乎一半的患者最终发展为癫痫，这是一种尽管进行了最佳药物治疗但仍自发复发性癫痫发作的病理状况。癫痫患者经常会经历严重的神经心理障碍，影响他们的学习，工作机会和生活质量。这在儿童癫痫发作中尤为明显。尽管进行了广泛的研究，但导致认知长期改变，有时进展为医学上难以治疗的癫痫发作的生物学机制仍然知之甚少。 严重难治性癫痫最常见的发展部位位于颞叶。对颞叶癫痫动物模型的几项研究表明，在长时间惊厥发作后3-7天内，NSC显著激活。这个过程无法在癫痫患者中进行研究，因为到目前为止，还没有可靠的生物标记物来追踪体内人类NSC的命运。最近，Savatic博士确定了NSC的代谢生物标志物，这使我们能够使用非侵入性高分辨率质子磁共振波谱（1HMRS）首次研究癫痫发作后人脑中NSC的命运。