PREVALENCE OF MORPHOLOGIC AND METABOLIC ABNORMALITIES IN HIV INFECTED AND UNINFE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项横断面调查，旨在评估艾滋病毒感染的女性青年的形态和代谢异常的患病率和严重程度，并评估与这些异常有关的药物和非药物因素。本研究旨在评估HIV感染与未感染的年轻女性之间在糖代谢、脂质、乳酸、身体成分和骨密度方面是否存在显著差异。此外，本研究将评估暴露于特定类别的抗逆转录病毒（ARV）药物是否与HIV感染者的代谢和形态异常以不同方式相关。本研究将阐明进一步深入研究的必要性，以了解蛋白酶抑制剂（PI）和非核苷类似物逆转录酶抑制剂（NNRTI）为基础的治疗在年轻女性中的病理生理学作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a cross-sectional survey designed to evaluate the prevalence and severity of morphologic and metabolic abnormalities in HIV infected female youth, and to assess the drug and non-drug factors related to these abnormalities. This study is designed to assess whether there exist significant differences in glucose metabolism, lipids, lactate, body composition and bone density between HIV infected and uninfected young women. Furthermore, this study will evaluate whether exposure to specific classes of antiretroviral (ARV) medications is associated with metabolic and morphologic abnormalities among HIV infected individuals in different ways. This study will elucidate the need for further in-depth study to understand the pathophysiological effects of protease inhibitor (PI) - and non-nucleoside analogue reverse transcriptase inhibitor (NNRTI) - based therapies in young females.