ATN 048: CORRELATES OF HBV-SPECIFIC B CELL MEMORY FOLLOWING VACCINATION IN HIV

ATN 048：HIV 疫苗接种后 HBV 特异性 B 细胞记忆的相关性

• 批准号: 7951110
• 负责人: LAWRENCE James D'ANGELO
• 金额: $ 0.28万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951110
• 关键词: Adolescent; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Evaluation; Funding; Grant; HIV; Hepatitis B Surface Antigens; Hepatitis B Virus; Immune response; Immunization; Institution; Laboratories; Memory B-Lymphocyte; Research; Research Personnel; Resources; Serological; Source; United States National Institutes of Health; Vaccination; base

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is an exploratory laboratory-based evaluation of cellular immune response to immunization with hepatitis B surface antigen in HIV-infected and HIV-uninfected adolescents. This is a substudy of ATN 024 and ATN 025. This substudy will compare cellular immune response in responders and nonresponders to immunization and also evaluate the relationship of these factors to the persistence of known correlates of serologic protection for the hepatitis B virus.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项探索性的基于实验室的评价，评价HIV感染和未感染HIV的青少年对B型肝炎表面抗原免疫的细胞免疫应答。这是ATN 024和ATN 025的子研究。该子研究将比较免疫应答者和免疫无应答者的细胞免疫应答，并评价这些因素与已知B型肝炎病毒血清学保护相关性持续性的关系。