ATN 015: SHORT-CYCLE THERAPY IN ADOLESCENTS WITH ESTABLISHED VIRAL SUPPRESSION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This Phase II HIV AIDS study is designed to obtain preliminary safety data on the concept of short cycle therapy (SCT) in adolescents. The primary objective of this study is to test the safety hypothesis that viral load rebound will not be increased in subjects on SCT compared to subjects on continuous highly antiretroviral therapy (HAART). As a Phase II study, its objective is to demonstrate with efficiency and precision the safety and preliminary efficacy of SCT in a small number of subjects tightly-defined by existing bio-behavioral data. The main aim of this study is to compare viral load suppression ( 1,000 copies/ml at time of viral load rebound will be assessed. The comparison period will be from study entry to administrative end of the study (24 weeks).