ATN 025: HEPATITIS B VACCINATION IN YOUTHS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项第二阶段的随机单盲试验，对150名HIV阴性、乙肝核心抗体、乙肝表面抗原和表面抗体阴性的年轻人进行了两种乙肝免疫方案的试验。随机化将受到限制，这样性别中的任何一个都不会超过两个手臂中任何一个的受试者的60%。疫苗接种将在0个月和6个月时分两次进行，主要结果是6个月后1个月出现血清反应。安全性和耐受性也将进行评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a Phase II, randomized, single-blinded trial of two Hepatitis B immunization regimens in 150 HIV-negative, Hepatitis B core antibody, Hepatitis B surface antigen, and surface antibody negative youth. The randomization will be restricted, so that the percentage of either gender does not exceed 60% of the subjects on either of the two arms. Vaccinations will be given in a two-dose refimer at 0 and six months and the primary outcome will be seroresponsiveness one month after the six-month dose. Safety and tolerability will also be assessed.