DE PEDIATRIC COBRE: ALTERATIONS AND RENOVATIONS CORE

DE PEDIATRIC COBRE：改造和翻新核心

• 批准号: 7610726
• 负责人: PAUL M FAWCETT
• 金额: $ 38.86万
• 依托单位: ALFRED I. DU PONT HOSP FOR CHILDREN
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610726
• 关键词: Age; Animal Housing; Animal Model; Animals; Area; Biological Sciences; Biomedical Research; Centers of Research Excellence; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Condition; Core Facility; Delaware; Facility Designs; Family suidae; Floor; Funding; Grant; Hospitals; Housing; Imaging Techniques; Institution; Label; Laboratories; Laboratory Research; Maintenance; Operative Surgical Procedures; Pediatric Hospitals; Pediatric Research; Physiological; Plants; Principal Investigator; Procedures; Recovery; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Room, Clean; Services; Sheep; Source; Sus scrofa; System; United States National Institutes of Health; Veterinarians; Work; animal facility; human disease; irradiation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Life Science Center (LSC) at the Alfred I duPont Hospital for Children in Wilmington, Delaware is a Nemours-funded core facility designed for conducting biomedical research using animal models of human disease. The physical plant encompasses approximately 7,000 sq ft of research laboratory, maintenance and animal holding facilities. There are 10 animal holding rooms, 4 wet laboratories or small animal procedure rooms, 1 major surgery room, 1 imaging and procedure suite, and an irradiation room, in addition to storage rooms and an automated cleaning room. Staffing of the center includes a manager, two animal caretakers, a surgical services technician and an attending veterinarian. The existing physical plant is located in a separate building near the hospital/research center. The LSC is aging. In addition to the need for expanded space, upgrades to critical infrastructure components, such as the electrical system and the HVAC system, are critically needed. In addition, there is an LSC Annex that consists of two small rooms (G46/48) located on the ground floor of the Research building, which cannot be utilized for survival surgery in its present condition. The background and objectives of the A&R project relate to the large animal holding room and storage area. The principal investigator (Shaffer) and the COBRE TI projects of Drs. Tsuda and Chidekel require the use of large animals (sheep and/or pigs). To accommodate these needs, the current LSC general storage room (#109) will be modified to meet animal housing and storage requirements. Renovations to Room #109 will include the addition of a dividing wall to produce two separate rooms. One room with be labeled 109A and will remain in use for LSC storage; Room 109B will become a holding/housing room for large animals. Originally, a recovery surgery suite for large animals was included in the COBRE A&R project; however, the initial bid on the project far exceeded the available funding, and in year #2-3, a decision was made to eliminate that aspect of the A/R core and focus on the holding room project. The objective of the A&R Core is to provide a significant upgrade to our existing vivarium facilities (Nemours Life Science Center). The Center for Pediatric Research will significantly increase demands for vivarium space and will initiate the use of new animal models within the Nemours Biomedical Research Institute. While the animal facility is sufficient for current small animal work, it does not meet the needs of several researchers who require or will require specialized physiological studies in small animals, nor does it provide sufficient large animal vivarium or child-relevant animal models. The planned renovations will create a large animal holding room, a procedure room for survival surgery on large animals and a procedure room for survival surgery on small animals.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 特拉华州威尔明顿市Alfred I Dupont儿童医院的生命科学中心（LSC）是由Nemours资助的核心设施，旨在使用人类疾病动物模型进行生物医学研究。 物理工厂包括大约7,000平方英尺的研究实验室，维护和动物持有设施。 除储藏室和一个自动清洁室外，还有10个动物握住房间，4个湿实验室或小动物程序室，1个主要手术室，1个成像和手术套件以及一个辐射室。 该中心的人员配备包括一名经理，两名动物护理人员，一名外科服务技术员和一名参加兽医。 现有的物理工厂位于医院/研究中心附近的一栋单独的建筑物中。 LSC正在衰老。 除了需要扩大空间外，还需要升级到关键基础设施组件（例如电气系统和HVAC系统）。 此外，还有一个LSC附件，该附件由位于研究大楼底楼的两个小房间（G46/48）组成，该房间不能用于目前的生存手术。 A＆R项目的背景和目标与大型动物持有室和存储区有关。 首席调查员（Shaffer）和Drs的Cobre Ti项目。 Tsuda和Chidekel需要使用大型动物（绵羊和/或猪）。 为了满足这些需求，当前的LSC通用储藏室（＃109）将被修改以满足动物住房和存储要求。 ＃109房间的翻新工程将包括增加一个分开的墙壁，以生产两个独立的房间。 一个带有标记为109a的房间，并将留在LSC存储中； 109b房间将成为大型动物的藏室/住房室。最初，在毛豆A＆R项目中包括了针对大型动物的恢复手术套件。但是，该项目的最初出价远远超过了可用的资金，在第2-3年，决定消除A/R核心的这一方面，并​​专注于Holding Room项目。 A＆R核心的目的是为我们现有的Vivarium设施（Nemours Life Science Center）提供大量升级。 小儿研究中心将显着增加对胎盘空间的需求，并将在Nemours生物医学研究所内使用新动物模型。 尽管动物设施足以进行当前的小动物工作，但它不满足几位需要或需要在小动物中进行专门生理研究的研究人员的需求，也不提供足够的大型动物植物或与儿童相关的动物模型。 计划进行的翻新将创建一个大型动物持有室，大型动物生存手术的程序室以及小动物生存手术的程序室。