DE PEDIATRIC COBRE: ALTERATIONS AND RENOVATIONS CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 位于特拉华州威尔明顿的阿尔弗雷德·I·杜邦儿童医院的生命科学中心(LSC)是内穆斯资助的核心设施，旨在使用人类疾病的动物模型进行生物医学研究。该实体工厂包括大约7000平方英尺的研究实验室、维护和动物饲养设施。除了储藏室和自动清洁室外，还有10个动物拘留室、4个湿实验室或小动物程序室、1个大手术室、1个成像和程序室和1个放射室。该中心的工作人员包括一名经理、两名动物饲养员、一名外科服务技术员和一名主治兽医。 现有的实体工厂位于医院/研究中心附近的一栋单独的建筑中。LSC正在老化。除了需要扩大空间外，迫切需要升级关键基础设施部件，如电气系统和暖通空调系统。此外，位于研究大楼一楼的LSC附楼由两个小房间(G46/48)组成，目前的状况不能用于生存手术。 A&R项目的背景和目标涉及大型动物拘留室和储藏区。首席研究员(Shaffer)和津田博士和Chidekel博士的Cobre TI项目要求使用大型动物(绵羊和/或猪)。为了满足这些需求，目前的LSC通用储藏室(#109)将进行改造，以满足动物的住房和储存要求。对109号房间的翻修将包括增加一面隔墙，以产生两个独立的房间。其中一个房间的标签为109A，将继续用于LSC存储；109B房间将成为大型动物的收容室/收容室。最初，Cobre A&R项目包括一个大型动物复苏手术套间；然而，该项目的初始出价远远超过可用资金，在#2-3年，决定取消A/R核心的这一方面，并将重点放在休息室项目上。 A&R中心的目标是对我们现有的间隔室设施(Nemour生命科学中心)进行重大升级。儿科研究中心将显著增加对隔室空间的需求，并将在内穆尔生物医学研究所内开始使用新的动物模型。虽然动物设施足以满足目前小动物工作的需要，但它不能满足需要或将需要对小动物进行专门生理学研究的几名研究人员的需要，也不能提供足够的大动物或与儿童相关的动物模型。计划中的翻修将创建一个大型动物拘留室、一个用于大型动物生存手术的程序室和一个用于小动物生存手术的程序室。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Life Science Center (LSC) at the Alfred I duPont Hospital for Children in Wilmington, Delaware is a Nemours-funded core facility designed for conducting biomedical research using animal models of human disease. The physical plant encompasses approximately 7,000 sq ft of research laboratory, maintenance and animal holding facilities. There are 10 animal holding rooms, 4 wet laboratories or small animal procedure rooms, 1 major surgery room, 1 imaging and procedure suite, and an irradiation room, in addition to storage rooms and an automated cleaning room. Staffing of the center includes a manager, two animal caretakers, a surgical services technician and an attending veterinarian. The existing physical plant is located in a separate building near the hospital/research center. The LSC is aging. In addition to the need for expanded space, upgrades to critical infrastructure components, such as the electrical system and the HVAC system, are critically needed. In addition, there is an LSC Annex that consists of two small rooms (G46/48) located on the ground floor of the Research building, which cannot be utilized for survival surgery in its present condition. The background and objectives of the A&R project relate to the large animal holding room and storage area. The principal investigator (Shaffer) and the COBRE TI projects of Drs. Tsuda and Chidekel require the use of large animals (sheep and/or pigs). To accommodate these needs, the current LSC general storage room (#109) will be modified to meet animal housing and storage requirements. Renovations to Room #109 will include the addition of a dividing wall to produce two separate rooms. One room with be labeled 109A and will remain in use for LSC storage; Room 109B will become a holding/housing room for large animals. Originally, a recovery surgery suite for large animals was included in the COBRE A&R project; however, the initial bid on the project far exceeded the available funding, and in year #2-3, a decision was made to eliminate that aspect of the A/R core and focus on the holding room project. The objective of the A&R Core is to provide a significant upgrade to our existing vivarium facilities (Nemours Life Science Center). The Center for Pediatric Research will significantly increase demands for vivarium space and will initiate the use of new animal models within the Nemours Biomedical Research Institute. While the animal facility is sufficient for current small animal work, it does not meet the needs of several researchers who require or will require specialized physiological studies in small animals, nor does it provide sufficient large animal vivarium or child-relevant animal models. The planned renovations will create a large animal holding room, a procedure room for survival surgery on large animals and a procedure room for survival surgery on small animals.