DE PEDIATRIC COBRE: ALTERATIONS AND RENOVATIONS CORE

DE PEDIATRIC COBRE：改造和翻新核心

• 批准号: 7720954
• 负责人: PAUL M FAWCETT
• 金额: $ 39.38万
• 依托单位: ALFRED I. DU PONT HOSP FOR CHILDREN
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720954
• 关键词: Age; Animal Housing; Animal Model; Animals; Area; Biological Sciences; Biomedical Research; Centers of Research Excellence; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Condition; Core Facility; Delaware; Facility Designs; Family suidae; Floor; Funding; Grant; Hospitals; Housing; Imaging Techniques; Institution; Label; Laboratories; Laboratory Research; Maintenance; Operative Surgical Procedures; Pediatric Hospitals; Pediatric Research; Physiological; Plants; Principal Investigator; Procedures; Recovery; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Room, Clean; Services; Sheep; Source; Sus scrofa; System; United States National Institutes of Health; Veterinarians; Work; animal facility; human disease; irradiation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Life Science Center (LSC) at the Alfred I duPont Hospital for Children in Wilmington, Delaware is a Nemours-funded core facility designed for conducting biomedical research using animal models of human disease. The physical plant encompasses approximately 7,000 sq ft of research laboratory, maintenance and animal holding facilities. There are 10 animal holding rooms, 4 wet laboratories or small animal procedure rooms, 1 major surgery room, 1 imaging and procedure suite, and an irradiation room, in addition to storage rooms and an automated cleaning room. Staffing of the center includes a manager, two animal caretakers, a surgical services technician and an attending veterinarian. The existing physical plant is located in a separate building near the hospital/research center. The LSC is aging. In addition to the need for expanded space, upgrades to critical infrastructure components, such as the electrical system and the HVAC system, are critically needed. In addition, there is an LSC Annex that consists of two small rooms (G46/48) located on the ground floor of the Research building, which cannot be utilized for survival surgery in its present condition. The background and objectives of the A&R project relate to the large animal holding room and storage area. The principal investigator (Shaffer) and the COBRE TI projects of Drs. Tsuda and Chidekel require the use of large animals (sheep and/or pigs). To accommodate these needs, the current LSC general storage room (#109) will be modified to meet animal housing and storage requirements. Renovations to Room #109 will include the addition of a dividing wall to produce two separate rooms. One room with be labeled 109A and will remain in use for LSC storage; Room 109B will become a holding/housing room for large animals. Originally, a recovery surgery suite for large animals was included in the COBRE A&R project; however, the initial bid on the project far exceeded the available funding, and in year #2-3, a decision was made to eliminate that aspect of the A/R core and focus on the holding room project. The objective of the A&R Core is to provide a significant upgrade to our existing vivarium facilities (Nemours Life Science Center). The Center for Pediatric Research will significantly increase demands for vivarium space and will initiate the use of new animal models within the Nemours Biomedical Research Institute. While the animal facility is sufficient for current small animal work, it does not meet the needs of several researchers who require or will require specialized physiological studies in small animals, nor does it provide sufficient large animal vivarium or child-relevant animal models. The planned renovations will create a large animal holding room, a procedure room for survival surgery on large animals and a procedure room for survival surgery on small animals.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 特拉华州威尔明顿阿尔弗雷德一世​​杜邦儿童医院的生命科学中心 (LSC) 是内穆尔资助的核心设施，旨在利用人类疾病的动物模型进行生物医学研究。 该实体工厂包括约 7,000 平方英尺的研究实验室、维护和动物饲养设施。 有10个动物保存室​​、4个湿实验室或小动物手术室、1个大手术室、1个成像和手术室、1个辐照室，此外还有储藏室和自动化清洁室。 该中心的人员包括一名经理、两名动物看护员、一名外科服务技术员和一名主治兽医。 现有的实体工厂位于医院/研究中心附近的一栋独立建筑内。 LSC 正在老化。 除了需要扩大空间外，还迫切需要升级关键基础设施组件，例如电气系统和暖通空调系统。 此外，研究大楼底层还有一个由两个小房间（G46/48）组成的LSC附楼，在目前的情况下无法用于生存手术。 A&R项目的背景和目标涉及大型动物饲养室和储存区。 首席研究员 (Shaffer) 和 Drs 的 COBRE TI 项目。 Tsuda 和 Chidekel 需要使用大型动物（绵羊和/或猪）。 为了满足这些需求，现有的 LSC 通用储藏室 (#109) 将进行改造，以满足动物饲养和储存的要求。 109 号房间的翻修将包括增加一堵分隔墙，以形成两个独立的房间。 一间标记为 109A 的房间将继续用于 LSC 存储； 109B 室将成为大型动物的饲养室。最初，COBRE A&R 项目中包含了大型动物的康复手术套件；然而，该项目的初始投标远远超出了可用资金，因此在#2-3 年，决定取消 A/R 核心的这一方面，并​​将重点放在等候室项目上。 A&R 核心的目标是对我们现有的动物园设施（内穆尔生命科学中心）进行重大升级。 儿科研究中心将显着增加对动物饲养场空间的需求，并将在内穆尔生物医学研究所内开始使用新的动物模型。 虽然动物设施足以满足当前的小动物工作，但它不能满足一些需要或将需要对小动物进行专门生理研究的研究人员的需求，也不能提供足够的大型动物饲养场或儿童相关的动物模型。 计划的翻修将创建一个大型动物饲养室、一个用于大型动物生存手术的手术室和一个用于小动物生存手术的手术室。