DE PEDIATRIC COBRE: ALTERATIONS AND RENOVATIONS CORE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 位于特拉华州威尔明顿的阿尔弗雷德一世杜邦儿童医院的生命科学中心（LSC）是内穆尔资助的核心设施，旨在使用人类疾病的动物模型进行生物医学研究。 物理工厂包括约7，000平方英尺的研究实验室，维护和动物饲养设施。 有10个动物饲养室，4个湿实验室或小动物手术室，1个大手术室，1个成像和手术室，一个辐照室，以及储藏室和自动清洁室。 该中心的工作人员包括一名经理、两名动物护理员、一名外科服务技术员和一名主治兽医。 现有的物理工厂位于医院/研究中心附近的一座独立建筑内。 LSC正在老化。 除了需要扩大空间外，还迫切需要对电气系统和暖通空调系统等关键基础设施部件进行升级。 此外，还有一个LSC附属建筑，由位于研究大楼一楼的两个小房间（G46/48）组成，目前无法用于生存手术。 A&R项目的背景和目标与大型动物饲养室和储存区有关。 主要研究者（Shaffer）和Tsuda和Chidekel博士的COBRE TI项目需要使用大型动物（绵羊和/或猪）。 为了满足这些需求，将对当前LSC一般储存室（#109）进行改造，以满足动物饲养和储存要求。 对109号房间的装修将包括增加一堵隔墙，以形成两个独立的房间。 一个房间标记为109 A，将继续用于LSC储存;房间109 B将成为大型动物的饲养/圈养室。最初，COBRE A&R项目中包括大型动物的恢复手术室;然而，该项目的初始投标远远超过了可用资金，在第2 -3年，决定取消A/R核心的这一方面，并专注于保持室项目。 A&R核心的目标是对我们现有的动物园设施（内穆尔生命科学中心）进行重大升级。 儿科研究中心将显著增加对动物园空间的需求，并将在Nemours生物医学研究所内开始使用新的动物模型。 虽然动物设施足以满足目前的小动物工作，但它不能满足需要或将需要在小动物中进行专门生理学研究的一些研究人员的需求，也不能提供足够的大型动物饲养场或儿童相关动物模型。 计划中的翻修将建立一个大型动物收容室，一个大型动物生存手术室和一个小动物生存手术室。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Life Science Center (LSC) at the Alfred I duPont Hospital for Children in Wilmington, Delaware is a Nemours-funded core facility designed for conducting biomedical research using animal models of human disease. The physical plant encompasses approximately 7,000 sq ft of research laboratory, maintenance and animal holding facilities. There are 10 animal holding rooms, 4 wet laboratories or small animal procedure rooms, 1 major surgery room, 1 imaging and procedure suite, and an irradiation room, in addition to storage rooms and an automated cleaning room. Staffing of the center includes a manager, two animal caretakers, a surgical services technician and an attending veterinarian. The existing physical plant is located in a separate building near the hospital/research center. The LSC is aging. In addition to the need for expanded space, upgrades to critical infrastructure components, such as the electrical system and the HVAC system, are critically needed. In addition, there is an LSC Annex that consists of two small rooms (G46/48) located on the ground floor of the Research building, which cannot be utilized for survival surgery in its present condition. The background and objectives of the A&R project relate to the large animal holding room and storage area. The principal investigator (Shaffer) and the COBRE TI projects of Drs. Tsuda and Chidekel require the use of large animals (sheep and/or pigs). To accommodate these needs, the current LSC general storage room (#109) will be modified to meet animal housing and storage requirements. Renovations to Room #109 will include the addition of a dividing wall to produce two separate rooms. One room with be labeled 109A and will remain in use for LSC storage; Room 109B will become a holding/housing room for large animals. Originally, a recovery surgery suite for large animals was included in the COBRE A&R project; however, the initial bid on the project far exceeded the available funding, and in year #2-3, a decision was made to eliminate that aspect of the A/R core and focus on the holding room project. The objective of the A&R Core is to provide a significant upgrade to our existing vivarium facilities (Nemours Life Science Center). The Center for Pediatric Research will significantly increase demands for vivarium space and will initiate the use of new animal models within the Nemours Biomedical Research Institute. While the animal facility is sufficient for current small animal work, it does not meet the needs of several researchers who require or will require specialized physiological studies in small animals, nor does it provide sufficient large animal vivarium or child-relevant animal models. The planned renovations will create a large animal holding room, a procedure room for survival surgery on large animals and a procedure room for survival surgery on small animals.