Role of estrogen and its receptors in ovarian cancer of the hen

雌激素及其受体在母鸡卵巢癌中的作用

• 批准号: 7683867
• 负责人: LINDSEY Starr Trevino
• 金额: $ 3.77万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7683867
• 关键词: Cancer Etiology; Cell Culture Techniques; Cessation of life; Contraceptive Agents; Disease Progression; Estradiol; Estrogen Nuclear Receptor; Estrogen Receptors; Estrogens; Etiology; Hormone replacement therapy; Human; Immunohistochemistry; In Vitro; Incidence; Lead; Malignant neoplasm of ovary; Mediating; Methods; Modeling; Molecular; Ovarian Tissue; Pathway interactions; Play; Risk; Role; Techniques; Western Blotting; Woman; design; human disease; in vivo; ovarian neoplasm; pill; receptor; steroid hormone; tumor; tumor initiation

Project summary: Ovarian cancer is the fifth leading cause of cancer death among women. It is known that there is an increased risk of ovarian cancer in women who are on estrogen-only hormone replacement therapy and possible decreased risk in women who take the contraceptive pill, lending support to the idea that steroid hormones are playing a role in the etiology of ovarian cancer. This project is designed to clarify the role of estrogen and its receptors in ovarian cancer of the domestic hen. The hen is a good model because it develops ovarian cancer with a high spontaneous incidence. The specific aims of this study are to: 1) determine whether ovarian cancer in the hen is estrogen dependent; 2) determine if the estrogen receptor is differentially regulated in ovarian cancer; 3) characterize the non-nuclear estrogen receptor; and 4) determine downstream pathways associated with estrogen receptor mediated proliferation. These questions will be answered using a variety of molecular techniques including PCR, Western blot, immunohistochemistry and microarray analyses, in vitro methods including cell culture, ex vivo (or in ovo) methods including CAM grafts of normal and tumor ovarian tissue, and in vivo methods including treatment of hens with estradiol. Once these questions are answered, we will have a better understanding of the role of estrogen and its receptors in ovarian cancer. These answers will also allow us to understand the mechanism of estrogen action promoting the formation or proliferation of ovarian tumors in the hen, which may be correlated to the role estrogen and its receptors m,ay play in human ovarian cancer. Furthermore, understanding estrogen's actions might lead to possible treatment options that could be applicable to human disease. Relevance: Ovarian cancer is the fifth leading cause of cancer death among women. Estrogens may promote ovarian tumor initiation or proliferation; therefore, it is important to understand its role in the origin or progression of the disease.

项目总结:

项目成果

Gene expression profiling reveals differentially expressed genes in ovarian cancer of the hen: support for oviductal origin?

基因表达谱揭示了母鸡卵巢癌中差异表达的基因：支持输卵管起源？

• DOI: 10.1007/s12672-010-0024-8
• 发表时间: 2010
• 期刊: Hormones & cancer
• 影响因子: 3
• 作者: Treviño,LindseyS;Giles,JamesR;Wang,Wei;Urick,MaryEllen;Johnson,PatriciaAnn
• 通讯作者: Johnson,PatriciaAnn

Oral contraceptives decrease the prevalence of ovarian cancer in the hen.

口服避孕药可降低母鸡卵巢癌的患病率。

• DOI: 10.1158/1940-6207.capr-11-0344
• 发表时间: 2012
• 期刊: Cancer prevention research (Philadelphia, Pa.)
• 作者: Treviño,LindseyS;Buckles,ElizabethL;Johnson,PatriciaA
• 通讯作者: Johnson,PatriciaA