Mitochondrial ribosomal pentatricopeptide domain proteins regulate protein synthesis in health and disease

线粒体核糖体五肽结构域蛋白调节健康和疾病中的蛋白质合成

• 批准号: nhmrc : 1005030
• 负责人: A/Pr Aleksandra Filipovska
• 金额: $ 29.61万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mitochondrial-ribosomal-pentatricopeptide-health-disease/109084
• 关键词: Mitochondrial; ribosomal; pentatricopeptide; domain; proteins

Mitochondria in our cells regulate energy production from food and play an important role in health and disease. Defects in mitochondrial protein synthesis lead to severe neurodegenerative and sensory diseases and may contribute to cancer and ageing. This research aims to investigate the role of mitochondrial proteins that regulate translation in mitochondrial diseases. Characterisation of these proteins provides an unexplored resource of potential disease modulators and drug targets.

我们细胞中的线粒体调节食物的能量产生，并在健康和疾病中发挥重要作用。线粒体蛋白质合成缺陷导致严重的神经退行性疾病和感觉疾病，并可能导致癌症和衰老。本研究旨在研究线粒体疾病中调节翻译的线粒体蛋白质的作用。这些蛋白质的表征提供了潜在疾病调节剂和药物靶点的未开发资源。