Targeting mitochondrial dysfunction in cardiovascular disease and cancer

针对心血管疾病和癌症中的线粒体功能障碍

• 批准号: nhmrc : GNT1154646
• 负责人: A/Pr Aleksandra Filipovska
• 金额: $ 79.23万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-mitochondrial-dysfunction-disease-cancer/1349150
• 关键词: Targeting; mitochondrial; dysfunction; cardiovascular; disease

Mitochondria are responsible for the production of more than 90% of the energy required by the cell. Therefore mitochondrial dysfunction they cause and contribute significantly to a range of diseases including metabolic disorders, neurodegenerative and cardiovascular diseases, diabetes, obesity and cancer. We will discover how mitochondrial function fails in these common diseases and develop targeted treatments for these diseases targeting mitochondrial dysfunction.

线粒体负责产生细胞所需能量的90%以上。因此，线粒体功能障碍会导致一系列疾病，包括代谢紊乱、神经退行性疾病和心血管疾病、糖尿病、肥胖症和癌症。我们将发现线粒体功能在这些常见疾病中是如何失效的，并针对这些疾病开发针对线粒体功能障碍的靶向治疗。