The structure and organization of the mitochondrial genome in health and mitochondrial disease

健康和线粒体疾病中线粒体基因组的结构和组织

• 批准号: nhmrc : 1041582
• 负责人: A/Pr Aleksandra Filipovska
• 金额: $ 36.92万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-organization-mitochondrial-mitochondrial-disease/111380
• 关键词: structure; organization; mitochondrial; genome; health

Mitochondrial DNA (mtDNA) mutations and mitochondrial dysfunction have been associated with a wide range of multi-system human diseases, although much remains to be learnt about molecular mechanisms in the pathogenesis of these diseases. Our goal is to understand how the expression of the mitochondrial DNA is regulated by mtDNA-binding proteins that will allow us to provide important insights into the molecular mechanisms of mitochondrial diseases.

线粒体DNA(MtDNA)突变和线粒体功能障碍与多种人类多系统疾病有关，但这些疾病发病的分子机制尚不清楚。我们的目标是了解线粒体DNA的表达是如何由线粒体DNA结合蛋白调节的，这将使我们能够为线粒体疾病的分子机制提供重要的见解。