The role of the cytoskeleton in communication between the L-type Ca2+ channel and the mitochondria in cardiac pathology

细胞骨架在心脏病理学中 L 型 Ca2 通道与线粒体通讯中的作用

• 批准号: nhmrc : 634501
• 负责人: A/Pr Aleksandra Filipovska
• 金额: $ 36.2万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-cytoskeleton-communication-cardiac-pathology/99558
• 关键词: role; cytoskeleton; communication; between; type

The L-type calcium channel is a protein in the membrane of heart muscle cells responsible for maintaining normal rhythm and contraction. We have shown that the channel can also regulate the function of the energy producing part of the cell (mitochondria). This occurs with the assistance of proteins that maintain cell architecture. We will test whether this association is altered in human disease where the cell architecture is disrupted to determine the mechanisms for poor energy supply.

L型钙通道是心肌细胞膜中的一种蛋白质，负责维持正常的节律和收缩。我们已经表明，该通道也可以调节细胞能量产生部分（线粒体）的功能。这在维持细胞结构的蛋白质的帮助下发生。我们将测试这种关联是否在人类疾病中改变，其中细胞结构被破坏，以确定能量供应不足的机制。