Regulation of mitochondrial gene expression in disease

疾病中线粒体基因表达的调节

• 批准号: nhmrc : 1058442
• 负责人: A/Pr Aleksandra Filipovska
• 金额: $ 46.49万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-mitochondrial-gene-expression-disease/454677
• 关键词: Regulation; mitochondrial; gene; expression; disease

Mitochondria are microscopic powerplants that produce most of the energy in cells. Genes that make mitochondrial proteins must work properly to make the energy our bodies require for health. Defects in the expression of mitochondrial genes cause debilitating diseases for which there are no cures currently. A/Prof Filipovska will use new technologies to understand how these mutations cause disease and develop therapeutics for treatments of diseases caused by defects in mitochondrial genes.

线粒体是微小的发电厂，产生细胞中的大部分能量。制造线粒体蛋白质的基因必须正常工作，以制造我们身体健康所需的能量。线粒体基因表达的缺陷会导致目前无法治愈的衰弱性疾病。A/ Filipovska教授将使用新技术来了解这些突变如何引起疾病，并开发治疗由线粒体基因缺陷引起的疾病的疗法。