GLUCOSE TRANSITIONS AMONG MEXICAN AMERICANS: PROXIMAL EVENTS & CONSEQUENCES

墨西哥裔美国人的血糖转变：近端事件

• 批准号: 7305019
• 负责人: CRAIG L HANIS
• 金额: $ 36.26万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7305019
• 关键词: Address; Affect; Attention; Behavioral; Biological; Centers of Research Excellence; Child; Cognitive; Communities; Companions; Complement; Complications of Diabetes Mellitus; Condition; County; Data; Deterioration; Development; Diabetes Mellitus; Diabetes prevention; Diet; Disease; Economics; Epidemiology; Evaluation; Event; Family; Frequencies; Glucose; Goals; Health; Health Status; Hispanics; Impaired fasting glycaemia; Individual; Inflammatory; Intervention; Knowledge; Lead; Left; Life; Life Style; Marketing; Measures; Media Intervention; Mental Health; Metabolic; Metabolic Control; Mexican Americans; Mexico; Minority; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Parents; Personal Satisfaction; Physical activity; Physiological; Pilot Projects; Population; Predisposition; Prevention strategy; Process; Public Health; Rate; Regulation; Research; Research Project Grants; Resources; Risk Factors; Socioeconomic Status; South Texas; Stress; Target Populations; Testing; Texas; Time; Training; Ursidae Family; Work; age group; blood glucose regulation; cognitive function; cohort; cost; environmental change; experience; glucose tolerance; health disparity; innovation; member; psychosocial; sobriety; social

The rapidly changing epidemiology of type 2 diabetes and its frequent companion obesity, doubling in the last two decades, have disproportionately impacted Mexican Americans; a minority with already marked health disparity in these conditions owing to higher initial frequencies. Recognizing these disparities, the proposed Center of Excellence on Diabetes in Americans of Mexican Descent aims to conduct research on the physiologic progression to diabetes and its complications among Mexican Americans, and to develop diabetes prevention strategies and test innovative approaches to effective interventions in a minority population severely affected by type 2 diabetes. This Center proposes an administrative core, a research core including three research projects and two pilot studies, a training core and a community engagement core. The Center of Excellence Research Core is addressing this interaction in type 2 diabetes through three coordinated projects with the goal of understanding and implementing interventions to slow the current rate of increase in the disease and its complications. This is one of the three projects of the research core and will focus on the transitions in glucose status from normal to pre-diabetes to overt diabetes. In 2001, we initiated the establishment of the Cameron County Hispanic (Mexican American) Cohort as a complement to our two decades of work in Starr County, Texas. Prior to the start of this project we will have completed detailed physical evaluations on some 1,500 individuals living in Brownsville located the US/Mexico border. Our first aim is to document changes proximal to the development of overt diabetes. While metabolic and inflammatory risk factors are known to predict the development of type 2 diabetes in the long term, little is known regarding these profiles at the time of and immediately preceding the transition to overt disease. We will assess the impact of metabolic and inflammatory profiles and their regulation at the time of conversion and 3 and 6 months earlier by intensively following 300 individuals with pre-diabetes from our established cohort. The second aim is to determine the consequences of transitions in glucose status on the mental health of individuals with diabetes and its interaction with socioeconomic status. As with the onset of diabetes, inflammatory processes are also associated with deterioration in cognitive function. Further, stress and mental health can be affected by changes in glucose control. Currently, there are inadequate data in these regards for Hispanics, in general, and specifically for Hispanics with type 2 diabetes. Changes in mental health are likely slower to develop, but by examining the full Cameron County Hispanic Cohort we will determine the contribution of diabetes status to cognitive health

2型糖尿病流行病学的迅速变化及其频繁的伴随肥胖， 在过去的二十年里，不成比例地影响了墨西哥裔美国人;少数民族已经明显 这些情况下的健康差异是由于初始频率较高。认识到这些差距， 拟议的墨西哥裔美国人糖尿病卓越中心旨在进行以下研究 墨西哥裔美国人糖尿病及其并发症的生理进展， 糖尿病预防战略和测试创新方法，以有效干预少数人 2型糖尿病患者的饮食习惯该中心提出了一个行政核心，一个研究 包括三个研究项目和两个试点研究，一个培训核心和一个社区参与 核心卓越研究核心中心通过三个方面来解决2型糖尿病的这种相互作用 协调项目，目标是了解和实施干预措施，以减缓目前的速度 疾病及其并发症的增加。 这是研究核心的三个项目之一，将重点关注葡萄糖状态从 从正常到糖尿病前期再到显性糖尿病2001年，我们发起成立了卡梅隆县 西班牙裔（墨西哥裔美国人）队列作为我们在斯塔尔县，得克萨斯州二十年的工作的补充。 在这个项目开始之前，我们将完成对大约1，500个 居住在位于美国/墨西哥边境的布朗斯维尔的个人。我们的首要目标是记录变化 接近显性糖尿病的发展。虽然已知代谢和炎症风险因素 预测2型糖尿病的长期发展，关于这些概况知之甚少， 转变为显性疾病的时间和之前。我们将评估代谢的影响 和炎症谱及其在转换时和3个月和6个月前的调节， 对我们已建立的队列中的300名糖尿病前期患者进行了密集随访。第二个目标是 确定血糖状态转变对糖尿病患者心理健康的影响 以及它与社会经济地位的相互作用。与糖尿病的发病一样，炎症过程也是 与认知功能恶化有关。此外，压力和心理健康可能会受到以下因素的影响： 血糖控制的变化。目前，西班牙裔在这些方面的数据不足，总的来说， 尤其是西班牙裔的2型糖尿病患者。心理健康的变化可能发展较慢，但 通过检查整个卡梅隆县西班牙裔队列，我们将确定糖尿病状态的贡献 认知健康