GLUCOSE TRANSITIONS AMONG MEXICAN AMERICANS: PROXIMAL EVENTS & CONSEQUENCES

2型糖尿病及其频繁伴随的肥胖症的流行病学迅速变化，在 在过去的二十年里，墨西哥裔美国人受到了不成比例的影响；少数人已经标记了 由于较高的初始频率，这些情况下的健康差异。认识到这些差距， 拟议的墨西哥裔美国人糖尿病英才中心旨在进行以下研究 墨西哥裔美国人发展为糖尿病及其并发症的生理学进展 糖尿病预防战略和测试有效干预少数人的创新方法 受2型糖尿病严重影响的人群。该中心提出了一个行政核心，一项研究 核心包括三个研究项目和两个试点研究、一个培训核心和一个社区参与 核心。卓越研究中心核心正在通过三个方面解决2型糖尿病的这种相互作用 协调项目，目的是了解和实施干预措施，以减缓目前的速度 疾病及其并发症的增加。 这是研究核心的三个项目之一，将重点放在从 从正常到糖尿病前期再到显性糖尿病。2001年，我们发起成立了卡梅伦县 西班牙裔(墨西哥裔美国人)作为我们在得克萨斯州斯塔尔县工作20年的补充。 在这个项目开始之前，我们将完成对大约1500个项目的详细物理评估 居住在布朗斯维尔的个人位于美国和墨西哥边境。我们的第一个目标是记录变化 处于显性糖尿病发展的近端。虽然已知代谢和炎症风险因素 预测2型糖尿病的长期发展，关于这些方面的情况在 过渡到显性疾病的时间和紧接其前的时间。我们将评估新陈代谢的影响 在转换时以及转换前3个月和6个月的炎性特征及其调节 从我们确定的队列中对300名糖尿病前期患者进行密集跟踪调查。第二个目标是 确定血糖状态变化对糖尿病患者心理健康的影响 以及它与社会经济地位的相互作用。与糖尿病的发病一样，炎症过程也 与认知功能的恶化有关。此外，压力和心理健康可能会受到 血糖控制的变化。目前，关于拉美裔美国人的这些方面的数据不足，总的来说， 特别是针对患有2型糖尿病的西班牙裔美国人。心理健康方面的变化可能发展得较慢，但 通过检查整个卡梅伦县西班牙裔队列，我们将确定糖尿病状况的贡献 为了认知健康

The rapidly changing epidemiology of type 2 diabetes and its frequent companion obesity, doubling in the last two decades, have disproportionately impacted Mexican Americans; a minority with already marked health disparity in these conditions owing to higher initial frequencies. Recognizing these disparities, the proposed Center of Excellence on Diabetes in Americans of Mexican Descent aims to conduct research on the physiologic progression to diabetes and its complications among Mexican Americans, and to develop diabetes prevention strategies and test innovative approaches to effective interventions in a minority population severely affected by type 2 diabetes. This Center proposes an administrative core, a research core including three research projects and two pilot studies, a training core and a community engagement core. The Center of Excellence Research Core is addressing this interaction in type 2 diabetes through three coordinated projects with the goal of understanding and implementing interventions to slow the current rate of increase in the disease and its complications. This is one of the three projects of the research core and will focus on the transitions in glucose status from normal to pre-diabetes to overt diabetes. In 2001, we initiated the establishment of the Cameron County Hispanic (Mexican American) Cohort as a complement to our two decades of work in Starr County, Texas. Prior to the start of this project we will have completed detailed physical evaluations on some 1,500 individuals living in Brownsville located the US/Mexico border. Our first aim is to document changes proximal to the development of overt diabetes. While metabolic and inflammatory risk factors are known to predict the development of type 2 diabetes in the long term, little is known regarding these profiles at the time of and immediately preceding the transition to overt disease. We will assess the impact of metabolic and inflammatory profiles and their regulation at the time of conversion and 3 and 6 months earlier by intensively following 300 individuals with pre-diabetes from our established cohort. The second aim is to determine the consequences of transitions in glucose status on the mental health of individuals with diabetes and its interaction with socioeconomic status. As with the onset of diabetes, inflammatory processes are also associated with deterioration in cognitive function. Further, stress and mental health can be affected by changes in glucose control. Currently, there are inadequate data in these regards for Hispanics, in general, and specifically for Hispanics with type 2 diabetes. Changes in mental health are likely slower to develop, but by examining the full Cameron County Hispanic Cohort we will determine the contribution of diabetes status to cognitive health