STRUCTURAL AND FUNCTIONAL STUDIES OF P97

P97的结构和功能研究

基本信息

  • 批准号:
    7597969
  • 负责人:
  • 金额:
    $ 0.61万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-03-01 至 2008-02-29
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are pursuing structural and functional studies of p97 (also called VCP, valosin-containing protein; VAT in Archaebacteria; and cdc48 in yeast), a distant homolog of NSF. p97 has been implicated in postmitotic homotypic membrane fusion of the endoplasmic reticulum (ER) and of the Golgi apparatus, assembly and growth of the nucleus, apoptosis, and DNA replication. It is also involved in the ubiquitin-dependent degradation pathway, as well as the extraction of misfolded luminal and membrane proteins from the ER for cytosolic degradation. We recently determined the crystal structure of the biologically complete p97/VCP hexamer complexed with a mixture of ADP and ADP.AlFx using diffraction data collected at SSRL and APS. The MAD dataset collected at SSRL provided the key to solve the structure. The structure revealed the quarternary configuration of the individual domains and the connecting linkers. Our crystal structure represents a snapshot of p97/VCP as it proceeds through its nucleotide hydrolysis cycle. Our future plans include structural studies of complexes involving adapter proteins and substrates for p97/VCP, to elucidate the mechanism and biological role of p97/VCP.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

AXEL T BRUNGER其他文献

AXEL T BRUNGER的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('AXEL T BRUNGER', 18)}}的其他基金

MECHANISM OF BOTULINUM NEUROTOXIN TARGET, SUBSTRATE, AND INHIBITOR INTERACTIONS
肉毒杆菌神经毒素靶标、底物和抑制剂相互作用的机制
  • 批准号:
    8362050
  • 财政年份:
    2011
  • 资助金额:
    $ 0.61万
  • 项目类别:
AXEL BRUNGER PRT TIME
阿克塞尔·布伦格 PRT 时间
  • 批准号:
    8362040
  • 财政年份:
    2011
  • 资助金额:
    $ 0.61万
  • 项目类别:
MECHANISM OF BOTULINUM NEUROTOXIN TARGET, SUBSTRATE, AND INHIBITOR INTERACTIONS
肉毒杆菌神经毒素靶标、底物和抑制剂相互作用的机制
  • 批准号:
    8169924
  • 财政年份:
    2010
  • 资助金额:
    $ 0.61万
  • 项目类别:
AXEL BRUNGER PRT TIME
阿克塞尔·布伦格 PRT 时间
  • 批准号:
    8169913
  • 财政年份:
    2010
  • 资助金额:
    $ 0.61万
  • 项目类别:
MECHANISM OF BOTULINUM NEUROTOXIN TARGET, SUBSTRATE, AND INHIBITOR INTERACTIONS
肉毒杆菌神经毒素靶标、底物和抑制剂相互作用的机制
  • 批准号:
    7954183
  • 财政年份:
    2009
  • 资助金额:
    $ 0.61万
  • 项目类别:
AXEL BRUNGER PRT TIME
阿克塞尔·布伦格 PRT 时间
  • 批准号:
    7954169
  • 财政年份:
    2009
  • 资助金额:
    $ 0.61万
  • 项目类别:
STRUCTURAL & FUNCTIONAL STUDIES OF HUMAN VESICULAR NEUROTRANSMITTER TRANSPORTERS
结构性
  • 批准号:
    7955126
  • 财政年份:
    2009
  • 资助金额:
    $ 0.61万
  • 项目类别:
AXEL BRUNGER PRT TIME
阿克塞尔·布伦格 PRT 时间
  • 批准号:
    7721750
  • 财政年份:
    2008
  • 资助金额:
    $ 0.61万
  • 项目类别:
STRUCTURAL AND FUNCTIONAL STUDIES OF P97
P97的结构和功能研究
  • 批准号:
    7721770
  • 财政年份:
    2008
  • 资助金额:
    $ 0.61万
  • 项目类别:
AXEL BRUNGER PRT TIME
阿克塞尔·布伦格 PRT 时间
  • 批准号:
    7597935
  • 财政年份:
    2007
  • 资助金额:
    $ 0.61万
  • 项目类别:

相似海外基金

Harnessing the potential of Archaea - Training Europe's next visionaries for an innovative and sustainable future
利用古生菌的潜力 - 培训欧洲的下一代有远见的人以实现创新和可持续的未来
  • 批准号:
    EP/Y031407/1
  • 财政年份:
    2024
  • 资助金额:
    $ 0.61万
  • 项目类别:
    Research Grant
The mobilome of the anaerobic methanotrophic archaea Methanoperedenaceae
厌氧甲烷氧化古菌 Methanoperedenaceae 的移动组
  • 批准号:
    DP240100992
  • 财政年份:
    2024
  • 资助金额:
    $ 0.61万
  • 项目类别:
    Discovery Projects
Asgard archaea: the first eukaryotic cells?
阿斯加德古菌:第一个真核细胞?
  • 批准号:
    DP230100769
  • 财政年份:
    2023
  • 资助金额:
    $ 0.61万
  • 项目类别:
    Discovery Projects
Probing the mechanisms that couple genome segregation to chromosome organization in Archaea
探讨古细菌基因组分离与染色体组织的耦合机制
  • 批准号:
    BB/X00645X/1
  • 财政年份:
    2023
  • 资助金额:
    $ 0.61万
  • 项目类别:
    Research Grant
Probing the mechanisms that couple genome segregation to chromosome organisation in Archaea
探讨古细菌基因组分离与染色体组织的耦合机制
  • 批准号:
    BB/X006506/1
  • 财政年份:
    2023
  • 资助金额:
    $ 0.61万
  • 项目类别:
    Research Grant
Enigmatic archaea in subsurface environments
地下环境中神秘的古细菌
  • 批准号:
    23H00387
  • 财政年份:
    2023
  • 资助金额:
    $ 0.61万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Functional and structural analysis of proline dehydrogenase for elucidation of proline biosynthesis in hyperthermophilic archaea
脯氨酸脱氢酶的功能和结构分析,用于阐明超嗜热古菌中脯氨酸的生物合成
  • 批准号:
    23K05658
  • 财政年份:
    2023
  • 资助金额:
    $ 0.61万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of novel denitrification process by methanotrophic archaea in bioelectroche mical system
生物电化学系统中甲烷氧化古菌新型反硝化工艺的发展
  • 批准号:
    22KF0377
  • 财政年份:
    2023
  • 资助金额:
    $ 0.61万
  • 项目类别:
    Grant-in-Aid for JSPS Fellows
Conference: 2023 Archaea: Ecology, Metabolism and Molecular Biology GRC and GRS The Root and Branch of Discovery: Lessons on Life from the Archaea
会议:2023 古细菌:生态学、代谢和分子生物学 GRC 和 GRS 发现的根源和分支:古细菌的生命教训
  • 批准号:
    2324896
  • 财政年份:
    2023
  • 资助金额:
    $ 0.61万
  • 项目类别:
    Standard Grant
Elucidation of biological and metabolic diversity of methanogenic archaea and reconstruction of subsurface carbon cycle
阐明产甲烷古菌的生物和代谢多样性以及重建地下碳循环
  • 批准号:
    23H03534
  • 财政年份:
    2023
  • 资助金额:
    $ 0.61万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了