IN-VITRO AND IN-VIVO ULTRASTRUCTURAL STUDIES OF NEURONAL INFLAMMATION

神经炎症的体外和体内超微结构研究

• 批准号: 7598373
• 负责人: ALBERT S LOSSINSKY
• 金额: $ 0.11万
• 依托单位: WADSWORTH CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598373
• 关键词: Blood - brain barrier anatomy; Brain; Candida albicans; Computer Retrieval of Information on Scientific Projects Database; District of Columbia; Endothelial Cells; Filler; Funding; Grant; Human; In Vitro; Inflammation; Institution; Meningitis; Neonatal; Neuraxis; Neurons; Neurosciences; Paper; Pathology; Rattus; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Societies; Source; Specimen; United States National Institutes of Health; Visit; Yeasts; abstracting; high voltage electron microscopy; in vivo; interest

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ABSTRACT Dr. Lossinsky has been a user of the RVBC HVEM facility for many years. He has undertaken a variety studies related to pathology of the central nervous system. In this reporting period, he was interested in invasion of brain endothelial cells by Candida albicans yeast, and inflammation in neonatal rat meningitis. In the previous reporting period, Dr. Lossinsky visited the RVBC to use the HVEM for recording stereo pairs of his specimens, and the following paper was presented: " Lossinsky, A.S., Fiala, M., Mukhtar, M., Filler, S.G. Ultrastructural studies on blocking Candida albicans invasion into the human blood-brain barrier in culture by remodeling the endothelial cytoskeletal infrastructure. Abstract to be presented at the Society for Neuroscience Convention, Washington, DC, November 15, 2005.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 摘要 博士Lossinsky多年来一直是RVBC HVEM设施的用户。 他进行了与中枢神经系统病理学相关的各种研究。 在本报告期内，他对白色念珠菌酵母侵入脑内皮细胞和新生大鼠脑膜炎的炎症感兴趣。 在上一次报告期间，Lossinsky博士访问了RVBC，使用HVEM记录他的标本的立体声对，并提交了以下论文： " Lossinsky，A.S.，Fiala，M.，Mukhtar，M.，Filler，S.G.通过重塑内皮细胞骨架结构阻断白念珠菌侵入人血脑屏障的超微结构研究。摘要将于2005年11月15日在华盛顿举行的神经科学学会大会上发表。