Social Influences on Early Adult Stress Biomarkers

社会对早期成人压力生物标志物的影响

• 批准号: 7264993
• 负责人: THOMAS W MC DADE
• 金额: $ 29.24万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7264993
• 关键词: Address; Adolescence; Adolescent; Adult; Advocate; Affect; Anxiety; Area; Behavior; Behavioral; Biological; Biological Markers; Biological Process; Cardiovascular system; Childhood; Cognitive; Communities; Data; Data Set; Depth; Development; Discipline; Disease Pathway; Economic Factors; Economics; Emotional Stress; Endocrine; Environment; Exposure to; Family; Goals; Health; Health Sciences; Household; Human; Human Development; Immune; Individual; Inequality; Inflammatory; Interdisciplinary Study; Intervention; Investigation; Joints; Longitudinal Studies; Measurement; Measures; Mental Health; Metabolic; Methodology; Methods; Modeling; Morbidity - disease rate; Nature; Neighborhoods; Numbers; Pathway interactions; Patient Self-Report; Pattern; Personal Satisfaction; Physiological; Physiology; Play; Policy Maker; Population; Process; Property; Range; Relative (related person); Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Role; Sample Size; Science; Shapes; Siblings; Skin; Social Environment; Socioeconomic Status; Statistical Models; Stress; Stress Tests; Surveys; Symptoms; Testing; Theoretical model; United States National Institutes of Health; Work; allostatic load; base; behavioral/social science; biological adaptation to stress; cohort; contextual factors; depressive symptoms; design; experience; health disparity; interdisciplinary approach; mortality; prevent; programs; psychosocial; racial and ethnic; response; social; social stress; stress related disorder; stressor; theories; tool; young adult

DESCRIPTION (provided by applicant): The goal of our project is to conduct a population-level investigation of social contexts, stress, and health. We integrate multiple biomarkers of stress with current theory and measurement tools from the social and behavioral sciences to gain a better understanding of how social contexts "get under the skin" to affect stress and health in young adults. We use data from four waves of the National Longitudinal Study of Adolescent Health (Add Health) in pursuit of three objectives: 1) Examine the interrelations among multiple subjective and physiological measures of stress; 2) Investigate how measures of socio-economic status, neighborhood quality, and interpersonal relationships in childhood/adolescence and over the transition to adulthood influence stress in early adulthood; and 3) Test competing theoretical models of the joint influence of socio- economic status, neighborhood quality, and interpersonal relationships on stress. We examine subjective measures of stress, including perceived stress, symptoms of depression, and symptoms of anxiety, as well as physiological measures of endocrine, cardiovascular, metabolic, immune, and inflammatory activity. We take advantage of the breadth and depth of the Add Health dataset to conduct the most comprehensive investigation to date of how social stress affects physical and mental health. Additionally, the large sample size and racial, ethnic, and economic diversity of Add Health allow us to investigate the extent to which stress leads to health disparities. Stress is a major contributor to morbidity and mortality, and investigating the physiological mechanisms through which social contexts affect human health can help investigators, clinicians, and policy makers to: a) identify adverse psychosocial environments; b) better understand predisease and disease pathways; and c) inform interventions to reduce exposure to stressors, reduce the adverse impact of stressors on physiology, and prevent the emergence of stress-related disorders.

描述（由申请人提供）：我们项目的目标是对社会背景、压力和健康进行人口水平的调查。我们将压力的多种生物标志物与当前社会和行为科学的理论和测量工具相结合，以更好地理解社会环境如何“深入皮肤”影响年轻人的压力和健康。我们使用来自全国青少年健康纵向研究（Add Health）的四波数据来追求三个目标：1)检验多种主观和生理压力测量之间的相互关系；2)调查社会经济地位、邻里关系、童年/青春期和成年过渡期的人际关系对成年早期压力的影响；3)检验社会经济地位、邻里关系和人际关系对压力共同影响的理论模型。我们研究了压力的主观测量，包括感知压力、抑郁症状和焦虑症状，以及内分泌、心血管、代谢、免疫和炎症活动的生理测量。我们利用“增加健康”数据集的广度和深度，对社会压力如何影响身心健康进行了迄今为止最全面的调查。此外，Add Health的大样本量和种族、民族和经济多样性使我们能够调查压力导致健康差异的程度。压力是导致发病率和死亡率的一个主要因素，调查社会环境影响人类健康的生理机制可以帮助研究者、临床医生和决策者：a)识别不利的社会心理环境；B)更好地了解疾病前期和疾病途径；c)告知干预措施以减少应激源暴露，减少应激源对生理的不利影响，防止应激相关疾病的出现。