HETERODYNE PHASE MICROSCOPY WITH A MACH-ZEHNDER INTERFEROMETER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们开发了一种基于马赫-曾德尔干涉仪的外差相位显微镜，用于测量活细胞中的纳米级运动。由数字合成射频场驱动的声光调制器被用来在采样路径和参考路径之间产生频率差，并使用高速cmos摄像机来成像所产生的干涉图案。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have developed a heterodyne phase microscope based on a Mach-Zehnder interferometer to measure nanometer-scale motions in living cells. Acousto-optic modulators driven by digitally synthesized RF fields are used to induce a frequency difference between sample and reference paths and a high speed CMOS camera is used to image the resulting interference pattern.