HETERODYNE PHASE MICROSCOPY WITH A MACH-ZEHNDER INTERFEROMETER

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们已经开发了一种基于马赫-曾德尔干涉仪的外差相位显微镜来测量活细胞中的纳米尺度运动。 声光调制器由数字合成的RF场驱动，用于在样品和参考路径之间引起频率差，并且高速CMOS相机用于对所产生的干涉图案成像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have developed a heterodyne phase microscope based on a Mach-Zehnder interferometer to measure nanometer-scale motions in living cells. Acousto-optic modulators driven by digitally synthesized RF fields are used to induce a frequency difference between sample and reference paths and a high speed CMOS camera is used to image the resulting interference pattern.