INTERFEROMETRIC MEASUREMENT OF NEURAL SIGNALS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们正在开发干涉技术，用于检测伴随神经元和神经纤维中电信号的快速光学和机械变化。目标是一种广泛适用的技术，用于同时监测许多神经元的活动，延长时间，并对细胞的侵袭最小。目前的研究涉及培养的大鼠海马神经元和神经元，也计划在体内研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are developing interferometric techniques for detecting the rapid optical and mechanical changes which accompany electrical signals in neurons and nerve fibers. The goal is a broadly applicable technique for monitoring the activity of many neurons simultaneously, for extended periods, and with minimal invasion to the cells. Current studies involve cultured rat hippocampal neurons and Aplysia neurons; in vivo studies are also planned.